Angiotensin-converting enzyme inhibition in hypertensive patients is associated with a reduction in the occurrence of atrial fibrillation

Journal of the American College of Cardiology
Philippe L L'AllierJean-Claude Tardif

Abstract

The objective of this study was to determine the effects of angiotensin-converting enzyme inhibition (ACEI) versus long-acting calcium-channel blockade (CCB) on atrial fibrillation (AF) in patients with hypertension. Atrial fibrillation is the most common significant cardiac arrhythmia, and angiotensin II has been implicated in its pathophysiology. This was a retrospective, longitudinal cohort study from a database of 8 million people in the U.S. Patients age > or =18 years with hypertension were eligible if they filled a prescription for either an ACEI or a CCB between January 1995 and June 1999. The use of all other antihypertensive medications was permitted. Patient chronic disease burden was assessed using a modified Charlson index. Patients were matched on a propensity score generated from a logistic regression model. A survival analysis approach was used to compare the incidence of AF between groups. The final cohorts were evaluated until June 2002, and the average follow-up was 4.5 years. After cohort matching, 10,926 patients were included in the analysis and divided equally into the ACEI and CCB groups. Mean patient age was 65 years. The adjusted hazards ratio (95% confidence interval [CI]) in the ACEI versus CCB group...Continue Reading

References

Oct 1, 1989·Cardiovascular Research·F SoltiA Juhász-Nagy
Jul 1, 1994·Journal of Molecular and Cellular Cardiology·C G BrillaK T Weber
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur
Oct 23, 1997·Circulation·B M PsatyP M Rautaharju
Feb 24, 2001·Journal of the American College of Cardiology·S S ChughB J Gersh
Mar 19, 2002·Hypertension·Eva GerdtsUNKNOWN Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
Feb 8, 2003·Hypertension·Paolo VerdecchiaCarlo Porcellati
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Francesca GensiniAntonio Michelucci
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jun 25, 2003·Journal of the American College of Cardiology·Koichiro KumagaiKeijiro Saku

❮ Previous
Next ❯

Citations

Dec 5, 2009·Aging Clinical and Experimental Research·Vasilios N NicolaouAlexandros K Tsakiris
Sep 3, 2008·European Journal of Clinical Pharmacology·Juan Carlos Estrada, Dawood Darbar
Sep 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Akiko Shiroshita-TakeshitaStanley Nattel
Mar 5, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Maya GuglinAnne B Curtis
Sep 4, 2008·Current Hypertension Reports·Tonje A AksnesSverre E Kjeldsen
May 12, 2012·Current Hypertension Reports·Athanasios J ManolisLeonidas E Poulimenos
Feb 26, 2008·Advances in Therapy·Mustafa TuncerBeyhan Eryonucu
Feb 9, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Anders AhlssonAnders Englund
Sep 20, 2005·International Journal of Cardiology·Panagiotis KorantzopoulosKonstantinos Siogas
Mar 8, 2005·Trends in Pharmacological Sciences·Eva DelpónJuan Tamargo
Feb 25, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA John Camm
Aug 9, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bart MaesenUlrich Schotten
Mar 17, 2009·BMC Cardiovascular Disorders·Thomas M MaddoxJohn S Rumsfeld
Nov 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideko Nakashima, Koichiro Kumagai
Dec 6, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichiro Kumagai
Jun 9, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Concepción MoroRoberto Matía
Jun 1, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Mohamed A El-HaddadSony Jacob
Oct 13, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Minoru Horie
Sep 1, 2006·Future Cardiology·Simone MuscoPeter R Kowey
Oct 30, 2009·Current Cardiology Reports·Orson Go, Clive Rosendorff
Aug 25, 2006·The Canadian Journal of Cardiology·Ahmad HersiD George Wyse
Apr 9, 2016·Methodist DeBakey Cardiovascular Journal·Adedotun A OgunsuaDavid D McManus
Feb 27, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dennis H LauPrashanthan Sanders
May 10, 2005·Journal of Cardiovascular Electrophysiology·Ruey J Sung, Michael R Lauer
Aug 2, 2007·Journal of Cardiovascular Electrophysiology·Francisco G Cosio
Sep 20, 2006·Pacing and Clinical Electrophysiology : PACE·Vishnu PatlollaAmin M Al-Ahmad
Jul 20, 2010·Pacing and Clinical Electrophysiology : PACE·Theodoros Zografos, Demosthenes G Katritsis
Oct 30, 2010·Pacing and Clinical Electrophysiology : PACE·Leonardo CalòFrancesco Fedele
Mar 31, 2009·European Journal of Internal Medicine·B SolunD Dicker
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vincent E HagensUNKNOWN RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation Study Group
Nov 23, 2006·International Journal of Cardiology·Arnljot TveitPal Smith
Oct 13, 2005·Expert Opinion on Pharmacotherapy·Anirban ChoudhuryGregory Y H Lip
Jun 8, 2017·Journal of Human Hypertension·F ShahidE Shantsila
Mar 1, 2005·Journal of the American College of Cardiology·Melvin M Scheinman, Edmund Keung
Mar 21, 2006·Journal of the American College of Cardiology·Martin RotterMichel Haïssaguerre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.