PMID: 2483430Jan 1, 1989Paper

Angiotensin converting enzyme inhibition: discrepancy between antihypertensive effect and suppression of enzyme activity.

Journal of Cardiovascular Pharmacology
B WaeberH R Brunner

Abstract

With chronic angiotensin converting enzyme (ACE) inhibition, blood pressure remains controlled throughout the day despite intermittent recovery of normal function of the renin-angiotensin system. This has been taken as evidence to suggest that the disappearance of angiotensin II (Ang II) from the circulation is not the main mechanism involved in the blood pressure-lowering action of ACE inhibitors. However, the degree of ACE inhibition is often not reliably estimated by the commonly used measurements of plasma ACE activity in vitro or plasma immunoreactive Ang II levels. The most appropriate method to assess ACE activity seems to be the measurement of the ratio between circulating angiotensin-(1-8)octapeptide and angiotensin I (Ang I) concentrations. The octapeptide and angiotensin I (Ang I) concentrations. The octapeptide Ang II can be measured precisely using high pressure liquid chromatography followed by a radioimmunoassay. Even using such improved methods, with long-term ACE inhibition, there exists a clear dissociation between the time course of ACE inhibition and that of the antihypertensive effect. Although it is attractive to speculate on this basis that other pathways such as blockade of tissue renin or enhanced vasod...Continue Reading

Citations

Jan 1, 1993·Clinical and Experimental Pharmacology & Physiology·R MorishitaT Ogihara
Apr 1, 1993·British Journal of Pharmacology·P ArvolaI Pörsti
May 15, 1997·The Journal of Clinical Investigation·C R EstherK E Bernstein
Nov 1, 1994·Clinical and Experimental Hypertension : CHE·G S StokesJ F Marwood
Aug 8, 2008·Best Practice & Research. Clinical Anaesthesiology·Matthias LangeAndrea Morelli
Sep 1, 1991·Hypertension·O A Carretero, A G Scicli

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