PMID: 9557931Apr 29, 1998Paper

Angiotensin converting enzyme inhibition modulates cardiac fibroblast growth

Journal of Hypertension
C GrohéH Vetter

Abstract

The progression of left ventricular hypertrophy and cardiac fibrosis in hypertensive heart disease is influenced by sex and age. Although angiotensin converting enzyme inhibition has been shown to prevent progression of the disease in postmenopausal women, the interaction of angiotensin II and estrogen in this process before and after the menopause is poorly understood. To investigate the influence of the angiotensin converting enzyme inhibitor moexiprilat on serum, estrogen and angiotensin II-induced cardiac fibroblast growth. Neonatal rat cardiac fibroblasts were incubated with 1 and 10% fetal calf serum, 10(-7) mol/l angiotensin II, 10(-9) mol/l estrone, 10(-9) mol/l 17beta-estradiol and 10(-8) mol/l moexiprilat. Proliferation was measured in terms of incorporation of bromodeoxyuridine. Western blot analysis was performed using antibodies directed against the growth-related immediate early genes c-fos and Sp-1. All experiments were performed at least three times. Fetal calf serum stimulated cardiac fibroblast proliferation (1% fetal calf serum 2.0+/-0.028-fold; 10% fetal calf serum 2.7+/-0.028-fold). Angiotensin II and estrone stimulated proliferation of cardiac fibroblasts grown in the absence of fetal calf serum (angiotens...Continue Reading

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Citations

Jan 29, 2000·The Journal of Thoracic and Cardiovascular Surgery·C A WalkerF G Spinale
Dec 15, 2005·Heart, Lung & Circulation·L BrownS A Doggrell
Mar 15, 2006·Transplantation·Ingo SchulteJürgen Borlak
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Amos Pines, Enrique Z Fisman
Jul 19, 2006·Canadian Journal of Physiology and Pharmacology·Michael P CzubrytBernard Abrenica
May 20, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sarah J GignacLucy E J Lee
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P H McNultyT Caulin-Glaser

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