PMID: 6170576Nov 1, 1981Paper

Angiotensin-converting enzyme inhibitor resets baroreceptor reflexes in conscious dogs

Hypertension
R HattonJ Conway

Abstract

The present experiments investigate whether the absence of tachycardia during lowering of blood pressure (BP) with an angiotensin-converting enzyme inhibitor (CEI) in salt-depleted dogs is due to an alteration in the activity of the baroreflex. Baroreflex activity was measured after pharmacological manipulation of BP using intravenous nitroglycerin or phenylephrine, and the heart period (R-R interval) relative to the arterial pressure pulse was recorded. The slope of the relationship between BP and R-R interval is a measure of the sensitivity of the baroreceptor reflex and displacement of the line indicates a change in the setpoint of BP. On normal sodium diet, the sensitivity and setpoint of the baroreflex were unaltered by the nonapeptide CEI given both intravenously and into a lateral cerebral ventricle. During salt depletion. however, intravenously but not centrally administered CEI altered the setpoint of the baroreflex without modifying the sensitivity. The alteration in the setpoint that occurred following intravenous CEI in the salt-depleted dog could well account for the fact that the fall in BP induced by CEI does not cause reflex tachycardia. These results indicate that circulating but not brain angiotensin II is ess...Continue Reading

References

May 4, 1978·The New England Journal of Medicine·H GavrasD N McKinstry
Mar 27, 1975·The New England Journal of Medicine·D H StreetenT G Dalakos
Dec 1, 1977·European Journal of Clinical Investigation·R FagardT Reybrouck
Oct 18, 1978·Pflügers Archiv : European journal of physiology·H G Glitsch, L Pott
Jan 1, 1974·Clinical and Experimental Pharmacology & Physiology·P I KornerJ B Uther
Aug 1, 1970·Clinical Science·C M FerrarioJ W McCubbin
Aug 1, 1970·Clinical Science·M D Joy, R D Lowe
Dec 1, 1970·The American Journal of Physiology·C S Sweet, M J Brody
May 1, 1974·European Journal of Pharmacology·B M GoldsteinM J Brody
Jan 1, 1972·Journal of Neural Transmission·K N SharmaS Dua-Sharma
Apr 1, 1971·Physiological Reviews·P I Korner
May 1, 1965·International Journal of Neuropharmacology·B G ZIMMERMAN, J GOMEZ

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·R CarrettaL Campanacci
Jan 1, 1986·European Journal of Clinical Pharmacology·A A AjayiJ L Reid
Aug 1, 1987·Cardiovascular Drugs and Therapy·J Schofer, W Bleifeld
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Feb 10, 2000·The American Journal of Pathology·D Mahieu-CaputoMarie-Claire Gubler
Nov 30, 2000·Obstetrics and Gynecology·R L FerrerJ Cornell
Feb 24, 2001·Lancet·H SajiR Ijiri
Aug 2, 2001·Lancet·J MartinovicMarie-Claire Gubler
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·J A MillarJ L Reid
Jul 1, 1985·Clinical and Experimental Pharmacology & Physiology·G R Bolt, P R Saxena
Jan 1, 1984·CRC Critical Reviews in Biochemistry·M A Ondetti, D W Cushman
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·K TakedaH Ijichi
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·D P CloughR Hatton
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·E E SlaterL H Hartley
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·A P NiarchosJ H Laragh
Jun 1, 1987·Archives internationales de physiologie et de biochimie·A M BalaszczukA Martinez Seeber
Aug 1, 1983·Kidney International·R A KellyS L Swartz
Sep 1, 1985·British Journal of Clinical Pharmacology·J F GiudicelliD Jacolot
Feb 1, 1987·British Journal of Clinical Pharmacology·K R Lees, J L Reid
Mar 1, 1988·British Journal of Clinical Pharmacology·G B KondoweD W Harron
Apr 7, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Casey A MuellerDane A Crossley
Sep 6, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Casey A MuellerDane A Crossley
Oct 1, 1985·British Heart Journal·B P McGrathC I Johnston
Oct 12, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Stephanie J Wehlage, Francine G Smith

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