PMID: 8996294Jan 1, 1997Paper

Angiotensin-converting enzyme inhibitor therapy affects left ventricular mass in patients with ejection fraction > 40% after acute myocardial infarction

Journal of the American College of Cardiology
D B JohnsonL J Dell'Italia

Abstract

We tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitor therapy decreases left ventricular (LV) mass in patients with a left ventricular ejection fraction (LVEF) > 40% and no evidence of heart failure after their first acute Q wave myocardial infarction (MI). Recently, ACE inhibitor therapy has been shown to have an early mortality benefit in unselected patients with acute MI, including patients without heart failure and a LVEF > 35%. However, the effects on LV mass and volume in this patient population have not been studied. Thirty-five patients with a LVEF > 40% after their first acute Q wave MI were randomized to titrated oral ramipril (n = 20) or conventional therapy (control, n = 15). Magnetic resonance imaging (MRI) performed an average of 7 days and 3 months after MI provided LV volumes and mass from summated serial short-axis slices. Left ventricular end-diastolic volume index did not change in ramipril-treated patients (62 +/- 16 [SD] to 66 +/- 17 ml/m2) or in control patients (62 +/- 16 to 68 +/- 17 ml/m2), and stroke volume index increased significantly in both groups. However, LV mass index decreased in ramipril-treated patients (82 +/- 18 to 73 +/- 19 g/m2, p = 0.0002) but not in the control pat...Continue Reading

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Citations

Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M LickerD R Morel
May 31, 2002·International Journal of Cardiology·Nicholas G BellengerDudley J Pennell
Feb 13, 2001·European Journal of Heart Failure·N GadsbøllP F Høilund-Carlsen
Jul 1, 2009·Heart Failure Clinics·Frank Grothues, Ruediger Braun-Dullaeus
Aug 3, 2010·European Journal of Heart Failure·Douglas L MannGerald D Buckberg
Jun 17, 1998·Cardiology Clinics·C M Kramer
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Mar 19, 2002·Hypertension·Saul G MyersonDudley J Pennell
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Sep 10, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Antònia AgustíJoan-Ramon Laporte
Oct 3, 2006·Current Opinion in Anaesthesiology·M Licker, D R Morel
Oct 3, 2006·Clinical Cardiology·Warren J Manning
Nov 23, 2020·Heart Failure Clinics·Aneesh S Dhore-Patil, Ashish Aneja

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