PMID: 9547444Apr 21, 1998Paper

Angiotensin-converting enzyme inhibitors in heart failure: physicians' prescribing behavior

Journal of Cardiac Failure
A FerreiraM Cerqueira-Gomes

Abstract

Several studies document an underuse of angiotensin-converting enzyme inhibitors (ACEIs) in heart failure (HF) patients, despite their proven efficacy and good tolerability. Also, there is some evidence that the doses used in clinical practice are far lower than those used in clinical trials. To identify patterns of ACEI use in HF patients this study examined data collected on admission day regarding demographic, clinical, and medical care characteristics of 355 patients hospitalized because of decompensated HF who were treated with and without ACEIs. Additionally, measures of in-hospital outcome were compared among the two groups. Fifty-eight point six percent of patients were receiving ACEIs at admission and 80.6% were treated with ACEIs during hospitalization. The average ACEI does was low. No differences were observed in age and measures of severity of HF between ACEI-prescribed and nonprescribed patients. Patterns that could explain ACEI underuse included female sex, lower systolic blood pressure, worse renal function, left ventricular diastolic dysfunction, use of alternate drugs (eg, spironolactone), and overall less intense medical management. Patterns associated with the use of lower doses of ACEIs included older age, ...Continue Reading

References

Aug 1, 1992·American Heart Journal·M J Eisenberg
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Citations

Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·R ReibisH Völler
Dec 15, 2005·Heart, Lung & Circulation·John H WlodarczykCate McCosker
Jun 14, 2000·Drugs·K Simpson, B Jarvis
Apr 1, 2000·European Journal of Heart Failure·M HoranK M McDonald
Aug 9, 2002·European Journal of Heart Failure·Cândida FonsecaHugo Madeira
Mar 20, 2003·European Journal of Heart Failure·Lisa G PontUNKNOWN Dutch Working Group on Heart Failure
Mar 27, 2012·European Journal of Preventive Cardiology·Ghassan MoubarakAlexis Mechulan

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