PMID: 17978595Nov 6, 2007

Angiotensin-converting enzyme inhibitors in the treatment of hypertension: an update

The Journal of Clinical Hypertension
William B White

Abstract

Angiotensin-converting enzyme inhibitors are an important treatment option for hypertension, especially when elevated blood pressure exists in the presence of diabetes mellitus, chronic kidney disease, or congestive heart failure. This article reviews some of the pathophysiologic mechanisms involved in patients with hypertension and these comorbidities and how they relate to the renin-angiotensin system (RAS). Inhibition of the RAS when utilized along with other antihypertensive medications has been particularly effective in hypertensive patients with type 2 diabetes, chronic kidney disease, and vascular disorders; consensus group guidelines have reflected this in their treatment recommendations. Clinical trial data demonstrate that the effectiveness of RAS blockers is enhanced by maximizing the daily dose and combining these medications with thiazide diuretics.

References

Mar 1, 1994·The Annals of Pharmacotherapy·T E Brown, B L Carter
Jan 20, 2000·The New England Journal of Medicine·Heart Outcomes Prevention Evaluation Study InvestigatorsGilles Dagenais
Sep 21, 2002·The American Journal of the Medical Sciences·John E HallPatricia M Dubbert
Dec 20, 2002·JAMA : the Journal of the American Medical Association·ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Apr 24, 2003·JAMA : the Journal of the American Medical Association·Henry R BlackCONVINCE Research Group
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianNational High Blood Pressure Education Program Coordinating Committee
Sep 19, 2003·Lancet·K M Fox, EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·James R Sowers
Dec 24, 2005·Diabetes Care·American Diabetes Association
Jan 13, 2006·Circulation·Thomas ThomAmerican Heart Association Statistics Committee and Stroke Statistics Subcommittee
Sep 5, 2006·The American Journal of Cardiology·Gilles DagenaisHOPE Study Investigators
Mar 31, 2007·European Heart Journal·Monica GianniEva Lonn
Mar 31, 2007·The Journal of Clinical Hypertension·William B White
Aug 7, 2007·American Journal of Hypertension·Andrew MoranRonald M Krauss

Citations

Aug 4, 2010·Autoimmunity Reviews·L TomasoniM Turiel
Apr 1, 2008·Journal of Cardiothoracic and Vascular Anesthesia·John G T Augoustides
May 8, 2015·Clinical & Experimental Ophthalmology·Justin C SherwinSimon N Thornton
Mar 21, 2013·Journal of Hypertension·Franz SchaeferMahomed Kadwa

Related Concepts

Angiotensin-Converting Enzyme Inhibitors
Cardiovascular Diseases
Endothelium, Vascular
Hypertensive Disease
Renin-angiotensin System

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.