Angiotensin-converting enzyme inhibitors in coronary artery disease and preserved left ventricular systolic function: a systematic review and meta-analysis of randomized controlled trials

Journal of the American College of Cardiology
Mouaz H Al-MallahW Douglas Weaver

Abstract

This study sought to assess the efficacy of angiotensin-converting enzyme inhibitors (ACEIs) in patients with coronary heart disease and preserved left ventricular (LV) function. The ACEIs have been shown to improve outcomes in patients with heart failure and myocardial infarction (MI). However, there is conflicting evidence concerning the benefits of ACEIs in patients with coronary artery disease (CAD) and preserved LV systolic function. An extensive search was performed to identify randomized, placebo-controlled trials of ACEI use in patients with CAD and preserved LV systolic function. Of 61 potentially relevant articles screened, 6 trials met the inclusion criteria. They were reviewed to determine cardiovascular mortality, nonfatal MI, all-cause mortality, and revascularization rates. We performed random-effect model meta-analyses and quantified between-studies heterogeneity with I(2). There were 16,772 patients randomized to ACEI and 16,728 patients randomized to placebo. Use of ACEIs was associated with a decrease in cardiovascular mortality (relative risk [RR] 0.83, 95% confidence interval [CI] 0.72 to 0.96, p = 0.01), nonfatal MI (RR 0.84, 95% CI 0.75 to 0.94, p = 0.003), all-cause mortality (RR 0.87, 95% CI 0.81 to 0.9...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Nov 9, 2004·The New England Journal of Medicine·Eugene BraunwaldUNKNOWN PEACE Trial Investigators
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN CAMELOT Investigators
Mar 5, 2005·The New England Journal of Medicine·Salim Yusuf, Janice Pogue

❮ Previous
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Citations

Jan 10, 2009·Pflügers Archiv : European journal of physiology·Zhen ShiGuo-Qing Zhu
Dec 2, 2010·Current Treatment Options in Cardiovascular Medicine·David J MaronRobert A O'Rourke
Nov 13, 2012·Current Treatment Options in Cardiovascular Medicine·Alicia MecklaiJudith Hochman
Aug 15, 2006·Lancet·Giuseppe Remuzzi, Piero Ruggenenti
Jan 25, 2007·Nature Clinical Practice. Cardiovascular Medicine·Lars Køber, Christian Torp-Pedersen
Jan 31, 2013·European Heart Journal·Amir-Ali FassaPhilippe Gabriel Steg
Feb 8, 2007·Current Opinion in Cardiology·Marie-Antoinette Rockx, Haissam Haddad
Oct 16, 2007·Heart·David M Shavelle
Nov 10, 2009·Canadian Journal of Physiology and Pharmacology·Ana R Lehenbauer LudkePawan K Singal
Sep 23, 2009·Current Medical Research and Opinion·Steven Yakubov
Jun 10, 2008·Cardiology Clinics·L Brent Mitchell
Apr 12, 2007·Journal of Thrombosis and Haemostasis : JTH·A W J H DielisP W de Leeuw
Nov 29, 2007·Pharmacotherapy·Toby C Trujillo, Paul P Dobesh
Mar 26, 2013·Current Opinion in Pharmacology·Richard J Sheppard, Ernesto L Schiffrin
Sep 25, 2014·Annual Review of Pharmacology and Toxicology·R D FeldmanS W Tobe
Sep 4, 2007·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Peter A McCulloughUNKNOWN IEPR Investigators
Jan 1, 2017·Indian Heart Journal·Sundeep MishraV K Bahl
Dec 10, 2016·Indian Heart Journal·Sundeep MishraVinay K Bahl
Sep 1, 2007·Circulation Research·Sylvia HeenemanMat J A P Daemen
Feb 12, 2014·Circulation·Philippe Gabriel Steg, Adrian Piers Cheong
Jul 9, 2010·Fundamental & Clinical Pharmacology·Giuseppe BorianiAngelo Branzi
Jul 2, 2010·British Journal of Pharmacology·Terry K W MaYat-Yin Lam
Jun 21, 2011·Seminars in Dialysis·Paolo CravediPiero Ruggenenti
May 25, 2010·Cardiovascular Therapeutics·Michael J Zellweger, Matthias E Pfisterer
Dec 3, 2014·Current Hypertension Reports·Steven G Chrysant, George S Chrysant
Nov 13, 2014·The Medical Journal of Australia·Peter L ThompsonChris Judkins
Aug 10, 2020·Advances in Therapy·Claudio Borghi, Stefano Omboni

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