PMID: 8592246Sep 1, 1995Paper

Angiotensin converting enzyme inhibitors in hypertension: potential problems

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
T F Antonios, G A MacGregor

Abstract

To review potential problems associated with the use of angiotensin converting enzyme (ACE) inhibitors in the treatment of patients with hypertension. ACE inhibitors cause a drop in blood pressure depending on the circulating level of angiotensin II. This may be a problem in patients with severe congestive heart failure, so that it is important to monitor the effect of the ACE inhibitor in this group. Hyperkalaemia can develop in patients with severe renal impairment and potassium plasma levels should be monitored. Renal impairment is another potential problem and in hypertensive patients renal function should be measured before, and a few weeks after, starting treatment. This is especially important when there is any possibility of fibromuscular hyperplasia or atheroscerotic renal artery stenosis. NON-PHYSIOLOGICAL PROBLEM: In addition to a cough, which is the most common problem, skin rashes, loss of taste, haematological effects and angioneurotic oedema are also encountered. The incidence of a cough with most ACE inhibitors is 5-10%. compared to other antihypertensive drugs, ACE inhibitors have the major advantage of being well tolerated by most patients with few side effects.

Citations

Sep 12, 2000·Current Hypertension Reports·M E Fabiani, C I Johnston
Mar 15, 2000·International Journal of Cardiology·R BoteroH Del Portillo
Sep 2, 2003·Peptides·Ewa D MarczakMasaaki Yoshikawa
Sep 20, 2008·Journal of Medicinal Food·Mariza FariaFlávia Maria Netto
Apr 12, 2006·Biological Chemistry·Pierre RedelinghuysEdward D Sturrock
Nov 25, 1995·Lancet·C I Johnston
Aug 21, 2014·BioMed Research International·Cheng-Liang XieYeung-Joon Choi
Sep 6, 2002·Bioorganic & Medicinal Chemistry·Manju BalaSantosh Pasha
Aug 31, 2010·Peptides·Dorien StaljanssensGuy Smagghe
Oct 22, 2008·Journal of Bioscience and Bioengineering·Yuka KobayashiShigeo Katoh
Apr 17, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M F M L NinahuamanM T R Lima-Landman
Sep 23, 2000·American Journal of Human Genetics·X ZhuM J Rieder
Nov 6, 2012·Food Chemistry·Makoto TomatsuSaori Takahashi
Apr 18, 2015·Annual Review of Food Science and Technology·Rotimi E Aluko
Aug 22, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ju-Hyun LeeTae-Hyun Yoo
Mar 14, 2018·Critical Reviews in Food Science and Nutrition·Yathisha U GMamatha B S
Jan 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bin LiYanjiang Qiao
Nov 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying SunXiaohui Zheng
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Md Yousof AliJae Sue Choi
Feb 22, 2013·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·Ping YangWenhong Cao
May 21, 2010·Journal of Agricultural and Food Chemistry·Fengjuan ZhouJiehua Wang
Jun 1, 2010·Journal of Agricultural and Food Chemistry·Masaaki TerashimaSaki Matsumura
Nov 14, 2013·Journal of Agricultural and Food Chemistry·Nadin Al ShukorGuy Smagghe
Sep 20, 2011·Journal of Agricultural and Food Chemistry·Masaaki TerashimaSaki Matsumura
Sep 8, 2018·Chemical Reviews·Allie Y ChenSeth M Cohen
Nov 30, 2012·Journal of Agricultural and Food Chemistry·Ching-Ching LauNorhaniza Aminudin
Jun 25, 2020·Journal of Agricultural and Food Chemistry·Dandan QianLe Qing Qu
Jun 17, 2006·The Journal of Organic Chemistry·Karl B Lindsay, Troels Skrydstrup

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