Angiotensin-converting enzyme inhibitors side effects--physiologic and non-physiologic considerations.

The Journal of Clinical Hypertension
Domenic A Sica

Abstract

Angiotensin-converting enzyme (ACE) inhibitors are increasingly recognized as having an important role in the treatment of hypertension and/or end-organ disease. The sheer number of ACE inhibitors in the United States--now numbering 10 different chemical entities--has created a sense of comfort with these compounds, which is particularly evident when these compounds are used in the patient with essential hypertension; conversely, when comorbid conditions are present in the ACE inhibitor-treated patient, circumstances change and physician vigilance becomes more of a necessity. ACE inhibitor therapy in patients with either cardiac and/or renal disease is as much an art as it is a science, and even in the most skilled hands can prove a challenging undertaking. This review discusses the physiologic and non-physiologic basis for side effects with ACE inhibition.

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Citations

Sep 21, 2016·Expert Opinion on Drug Safety·Ada OffurumTanisha Gooden
Aug 9, 2006·Congestive Heart Failure·Domenic A Sica, Lisa Brath
Aug 18, 2005·The Journal of Clinical Hypertension·Domenic A Sica
Aug 18, 2005·The Journal of Clinical Hypertension·William J Elliott
Jun 27, 2019·International Journal of Molecular Sciences·Da-Tong JuChih-Yang Huang
May 17, 2021·Pharmacology & Therapeutics·Juan TamargoEva Delpón
Sep 8, 2018·Chemical Reviews·Allie Y ChenSeth M Cohen

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