Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Yi HuangChunZhen Huang

Abstract

Studies investigating the association between the intron 16 insertion/deletion (I/D) polymorphism (rs4646994) in the angiotensin-converting enzyme (ACE) gene and risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratios (OR) and 95% confidence limits (CLs) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race. This meta-analysis included six case-control studies, which included 744 ICH cases and 1411 controls. The combined results based on all studies showed that ICH cases had a significantly lower frequency of ID genotype (OR (codominant model) = 0.43, 95% CL = 0.22, 0.84, p = 0.01). In the subgroup analysis by race, we found that ICH cases had a significantly lower frequency of II genotype in Asians (OR (recessive model) = 0.50, 95% CL = 0.38, 0.66, p < 0.001; OR (codominant model) = 0.25, 95% CL = 0.09, 0.71, p = 0.009). In conclusion, our meta-analysis suggests that ACE I/D polymorphisms are associa...Continue Reading

References

Nov 1, 1986·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
May 1, 1997·American Journal of Hypertension·J R JengS M Shieh
Oct 10, 1998·American Journal of Hematology·H TakahashiA Takada
Apr 28, 2004·Archives of Internal Medicine·Jonathan RosandSteven M Greenberg
Nov 27, 2004·Stroke; a Journal of Cerebral Circulation·Mohammad Saeed
Aug 13, 2005·Critical Care Medicine·Michel T Torbey
Jan 20, 2006·Journal of the American Geriatrics Society·Jun Harada, Kiyohisa Sekizawa
Aug 30, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C-M ChenG-J Lee-Chen
Jan 8, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Vasudevan RamachandranRusni Mohd Jas
Apr 13, 2010·Neurobiology of Aging·Sophie Domingues-MontanariStroke Project Cerebrovascular Diseases Study Group, Spanish Society of Neurology
Apr 27, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Maha Saber-AyadSanaa Abdel-Shafy
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·William J Powers
Jan 25, 2011·Pharmacogenetics and Genomics·Efthimios DardiotisGeorgios M Hadjigeorgiou
Jan 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS· Yu JinJan A Staessen
Mar 26, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Syed Kashif Nawaz, Shahida Hasnain
Jun 29, 2011·Journal of Neurosurgical Anesthesiology·Jonatan Myrup StaalsøNiels Vidiendal Olsen
Aug 6, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Dong Hwan KimHyung Hwan Baik
Aug 9, 2011·Genetic Testing and Molecular Biomarkers·Rongjun ZhangWei Shao
Nov 15, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Fatemeh SafariAli Khoshbaten
Dec 27, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Usha K MisraBalraj Mittal
Jan 27, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Young Ho LeeGwan Gyu Song
Apr 3, 2012·Neurosurgical Focus·Prachi MehndirattaWarren R Selman
May 5, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Rizk El-BazMohammed Abd El-Kader Sobh
Oct 6, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wei LiuQi Pang
Nov 3, 2012·PloS One·Charles H GreenbergSteven M Greenberg

Citations

Jul 16, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A KumarM Tripathi
Dec 17, 2015·Nature Reviews. Neurology·Amanda M CarpenterCharles J Prestigiacomo
Aug 5, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Francisco WestermeierSergio Lavandero
Oct 6, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Abualgasim Elgaili AbdallaJianping Xie
Dec 6, 2019·Neuromolecular Medicine·Kanika VasudevaAnjana Munshi

Methods Mentioned

BETA
genotyping

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.