Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study

European Journal of Medical Research
Luciana N Cosenso-MartinJosé Fernando Vilela-Martin

Abstract

The absence of nocturnal blood pressure dipping (ND) identified by 24-h ambulatory blood pressure monitoring (ABPM) correlates with a worse cardiovascular prognosis. The renin-angiotensin system influences blood pressure levels and the occurrence of target organ damage (TOD). Thus, the aim of this study was to correlate the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism with the 24-h blood pressure profile and TOD in hypertensive individuals. 155 non-diabetic hypertensive individuals on antihypertensive treatment underwent ABPM. Peripheral blood samples were drawn for biochemistry and genetic analysis of the ACE I/D polymorphism by polymerase chain reaction. ND was defined as ≥10 % differences in the mean systolic blood pressure (BP) during wakefulness and sleep. There were no differences in clinical or biochemical variables or TOD in respect to ND status, except for higher BP levels during sleep (p < 0.001) in non-dippers. There was significant difference in the prevalence of left ventricular hypertrophy (LVH) between ACE genotypes (II: 13.0 %; ID: 34.1 %; DD: 46.5 %; p value = 0.024) with an increased risk in carriers of the DD genotype (OR = 5.80; IC 95 % 1.50-22.44; p value = 0.011). Carriers...Continue Reading

References

Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
Sep 1, 1982·Hypertension·J M KotchenT A Kotchen
Feb 1, 1997·Journal of the American College of Cardiology·F PerticoneP L Mattioli
Sep 16, 1999·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K KarioK Shimada
May 23, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S WuH Nie
May 23, 2002·Journal of Hypertension·Mitsunobu MatsubaraYutaka Imai
Jun 13, 2003·The New England Journal of Medicine·Denis L ClementUNKNOWN Office versus Ambulatory Pressure Study Investigators
Sep 26, 2003·Journal of Hypertension·Maurizio CastellanoUNKNOWN Molecular Genetic Study Group of the Italian Society of Hypertension
Sep 24, 2005·Pediatric Transplantation·Erkin SerdarogluAfig Berdeli
Mar 6, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S R S FreitasI L Cordovil
Dec 20, 2007·American Journal of Hypertension·Daniel J BrotmanDonald G Vidt
May 24, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Leonelo E BautistaGermán Gamarra
Jan 8, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Vasudevan RamachandranRusni Mohd Jas
Apr 24, 2010·Arquivos brasileiros de cardiologia·Renan Oliveira Vaz-de-MeloJosé Fernando Vilela Martin
Jul 27, 2010·Clinical Biochemistry·Asad Vaisi-RayganiTayebeh Pourmotabbed
Oct 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alon FarfelZvi Farfel
Dec 15, 2010·Journal of Clinical Pharmacology·Bettina A HamelinJacques Turgeon
Jan 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS· Yu JinJan A Staessen
Mar 10, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Victor Mor-AviJose Luis Zamorano
Mar 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nozomi KatoHiromi Rakugi
Nov 17, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Zhen ChenHongbo Qi
Oct 24, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Evgeny A ReshetnikovMikhail I Churnosov

❮ Previous
Next ❯

Citations

May 4, 2016·Current Cardiology Reports·Alejandra Gutierrez, Mina K Chung
Sep 23, 2018·Journal of Cellular Biochemistry·Aifen LiuXiaozheng Song

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
electrophoresis
coronary artery bypass

Software Mentioned

Minitab

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.