PMID: 8610309Mar 1, 1996Paper

Angiotensin-converting enzyme insertion/deletion polymorphism and cerebrovascular disease

Stroke; a Journal of Cerebral Circulation
A CattoP J Grant

Abstract

There is evidence that an allelic variation in the angiotensin-converting enzyme (ACE) gene may confer an increased risk of vascular disease. The roles of the ACE insertion/deletion polymorphism and circulating ACE levels are unknown in cerebrovascular disease. We studied an insertion/deletion polymorphism within intron 16 of the ACE gene by polymerase chain reaction and plasma ACE activity in 467 cases of stroke, the pathological type of which was established by cranial CT, and 231 control subjects. ACE genotype and activity were related to stroke type and mortality at 4 weeks and 3 months. No difference in genotype frequency was observed between all subjects with stroke and control subjects or between control subjects and subjects with cerebral infarction or cerebral hemorrhage. Plasma ACE activity was significantly lower in stroke patients at presentation (64.1 IU/L) than in control subjects (79.6 IU/L; P<.0001). Twenty-one patients (4.5%) with cerebral infarction died within 4 weeks and 56 patients (12%) within 3 months. These patients had significantly lower plasma ACE activity than patients who survived. There was some evidence that risk of death within 4 weeks increased with the number of D alleles (P=.02). Among survivo...Continue Reading

References

Apr 15, 1992·Biochemical and Biophysical Research Communications·R Y ZeeB J Morris
Jun 27, 1989·Biochemistry·M R Ehlers, J F Riordan
Jan 1, 1989·Journal of Clinical Pathology·J SyrjänenC P Maury
Mar 16, 1995·The New England Journal of Medicine·K LindpaintnerC H Hennekens
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Oct 1, 1993·PCR Methods and Applications·V ShanmugamB K Saha

❮ Previous
Next ❯

Citations

Dec 27, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Usha K MisraBalraj Mittal
Jul 3, 2007·Current Treatment Options in Cardiovascular Medicine·Agnieszka SlowikAndrzej Szczudlik
Jun 1, 2002·Journal of the Neurological Sciences·Ryuichi OhkuboMitsuhiro Osame
May 3, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P MoayyediA J Catto
Aug 30, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C-M ChenG-J Lee-Chen
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Domingues-MontanariJ Montaner
Jul 7, 2000·Journal of Medical Genetics·M KeramatipourD C Rubinsztein
Mar 7, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·P Sharma
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·A HassanJ M Bamford
Dec 25, 2009·Circulation. Cardiovascular Genetics·Stéphanie Debette, Sudha Seshadri
Jul 10, 2003·BMC Neurology·James F MeschiaUNKNOWN Ischemic Stroke Genetics Study
Mar 13, 2012·Neurology India·Baoqiong LiuQidong Yang
Jun 29, 2011·Journal of Neurosurgical Anesthesiology·Jonatan Myrup StaalsøNiels Vidiendal Olsen
Mar 31, 1999·Current Opinion in Neurology·A Elbaz, P Amarenco
Oct 27, 2004·Expert Review of Cardiovascular Therapy·Vasamtha PadmaMajaz Moonis
Dec 22, 2004·The Journal of Physiology·Leigh Anderson
May 7, 2002·American Journal of Medical Genetics·Svenja BussUlrich Finckh
Mar 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shumin DengHe Zhiyi
Jan 22, 2015·Meta Gene·Murali VijayanBalakrishnan Karuppiah
Jul 27, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fiona J CarrAnna F Dominiczak
Oct 16, 2007·Experimental Physiology·Hugh S Markus
May 18, 2006·Acta Ophthalmologica Scandinavica·Elke SchäferAnton Haas
Apr 29, 2005·Brain Research. Molecular Brain Research·Kimiaki UtsugisawaYasuo Terayama
Feb 1, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nese TuncerIhsan Kara
Apr 2, 2013·Neurological Research·Jayantee KalitaBalraj Mittal
Jul 13, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Satrupa DasAnjana Munshi
Jun 16, 2000·Journal of the American Geriatrics Society·R D PollakA Blumenfeld
Jul 30, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Magdy A MostafaOsama M Abdulghany

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.