PMID: 7025965Nov 2, 1981Paper

Angiotensin generation in the brain and drinking: indications for the involvement of endopeptidase activity distinct from cathepsin D

Brain Research
J A TonnaerW de Jong

Abstract

The dipsogenic activity of two artificial renin substrates, tetradecapeptide and tridecapeptide, was studied. The dose-response curves obtained with these peptides, following intracerebroventricular administration, were similar to that of angiotensin I. The angiotensin II antagonist, Sar1, Ala8-angiotensin II, inhibited the dipsogenic effect of tetradecapeptide, indicating the conversion of the latter peptide into angiotensin II. The lower dipsogenic activity of tridecapeptide points to a conversion of this renin substrate into angiotensin III. Specific inhibition of tetradecapeptide induced drinking by the endopeptidase inhibitor N-acetyl-pepstatin suggests the involvement of an endopeptidase in the conversion of the renin substrates in the brain. Two endopeptidases present in the brain (cathepsin D and renin), were compared with respect to their capacity to generate angiotensin I from artificial renin substrate in vitro. Cathepsin D was active under only acidic pH conditions, whereas renin showed a wider pH range with maximal activity in the non-acidic region. Moreover, cathepsin D did not generate angiotensin I from natural, cerebrospinal fluid-angiotensinogen in vitro, and lacked dipsogenic activity following central admini...Continue Reading

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Citations

Oct 13, 2007·Digestive Diseases and Sciences·Arthur S Brecher, Rachel Dubord
May 1, 1983·Pharmacology, Biochemistry, and Behavior·R Di NicolantonioJ S Hutchinson
Mar 1, 1983·Brain Research Bulletin·J A TonnaerW de Jong
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·E J SybertzM Czarniecki
May 1, 1987·Journal of Neurochemistry·M AllardJ D Vincent
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J A TonnaerW de Jong
Mar 15, 1983·European Journal of Biochemistry·J A TonnaerD De Wied
Jan 12, 2020·Current Hypertension Reports·Pablo NakagawaCurt D Sigmund
Jul 23, 1998·Physiological Reviews·J T Fitzsimons

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