Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

Experimental & Molecular Medicine
H Arzu ErgenTurgay Isbir

Abstract

Non-insulin dependent diabetes mellitus is often associated with some complications such as nephropathy, retinopathy and neuropathy. Genes of the renin angiotensin system are potential candidate genes for diabetic complications. We investigated the relationship between angiotensin converting enzyme (ACE) gene polymorphism in type 2 diabetic patients with and without diabetic nephropathy. Seventy five patients (25 type 2 diabetic patients with nephropathy, 50 type 2 diabetic patients without nephropathy) and 37 healthy controls were studied. Gene polymorphism of ACE was determined by PCR (polymerase chain reaction) amplification using allele-spesific primers. The frequencies of ACE DD, ID and II genoypes among the patients with type 2 diabetic patients were found 48%, 42%, 10% whereas in control subjects, 27%, 60%, 13% respectively. Type 2 diabetic patients carrying DD genotype without nephropathy increased 1.77 fold than control subjects (P < 0.05). There is no significant correlation between diabetic nephropathy and ACE gene polymorphism. But we found that ACE DD genotype increased significantly in type 2 diabetic patients compared to control subjects (P <.05).

Citations

Jul 13, 2013·Biochemical Genetics·Ravindra KumarSarita Agarwal
Oct 30, 2010·Indian Journal of Human Genetics·Jaime J JayapalanSiew P Chan
Mar 17, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thouraya BaroudiAmel Benammar-Elgaaied
Jul 23, 2013·Indian Journal of Endocrinology and Metabolism·Sanjay KalraK M Prasanna Kumar
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Guldal Inal GultekinTurgay Isbir
Apr 22, 2017·Indian Journal of Clinical Biochemistry : IJCB·G K BhattiB Singh
May 5, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Rizk El-BazMohammed Abd El-Kader Sobh
Apr 12, 2005·Advances in Chronic Kidney Disease·Josette WilliamDaniel Batlle

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