Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension

Hypertension
H HiragaG Kajiyama

Abstract

We undertook the present study in 66 Japanese patients with essential hypertension to identify genetic factors associated with salt sensitivity. Patients were classified into salt-sensitive or salt-resistant groups on the basis of changes in their mean blood pressures from a week of a low salt diet (50 mmol/d) to a week of a high salt diet (340 mmol/d). Salt sensitivity and resistance were studied in relation to a 287-bp insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme gene detected by a polymerase chain reaction method and the haptoglobin phenotype determined by polyacrylamide gel electrophoresis. Patients with the angiotensin I-converting enzyme gene genotype II were more apt to be salt sensitive than patients with the ID and DD genotypes, although plasma renin activity was similar in each group. The frequency of the I allele in the salt-sensitive group was significantly higher than that in the salt-resistant group (chi2 = 7.4, odds ratio = 2.78). However, there was no significant relationship between haptoglobin phenotype and salt sensitivity. These data suggest that an I/D polymorphism of the angiotensin I-converting enzyme gene is a genetic factor associated with salt sensitivity of blood pressu...Continue Reading

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Citations

Sep 12, 2001·Current Hypertension Reports·S T TurnerE Boerwinkle
Aug 25, 2001·Paediatric and Perinatal Epidemiology·C HolzmanUNKNOWN Prematurity Study Group
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ling ZhangMasaaki Muramatsu
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Jun 18, 2004·Journal of Hypertension·Esther BeeksPeter W de Leeuw
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Apr 13, 2012·Journal of Hypertension·Tanika N Kelly, Jiang He
Dec 14, 2012·Expert Review of Clinical Pharmacology·Murielle Bochud, Idris Guessous
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Jan 12, 2019·Journal of Human Hypertension·Yang LiuJiang He
Feb 18, 2003·Current Opinion in Nephrology and Hypertension·Pedro A JoseRobin A Felder

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