PMID: 7028609Nov 1, 1981Paper

Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism

Hypertension
D T FeiJ P Coghlan

Abstract

The arterial and central venous concentrations of angiotensin I (AI), Val5-angiotensin II ([Val5]AII), and Val5-angiotensin III ([Val5]AIII(2-8)) were quantitatively determined in conscious sheep before and after sodium depletion. All three angiotensins were elevated in blood with progressive sodium loss. During sodium deficiency the arteriovenous concentration ratios (A:V) of AI, [Val5]AII, and [Val5]AIII(2-8) were found to be 0.48 +/- 0.03 (n = 9), 1.30 +/- 0.05 (n = 16), and 1.52 +/- 0.05 (n = 11) respectively. Intravenous infusion of [Val5]AII or [Val5]AIII(2-8) significantly elevated the A:V of respective angiotensins, being 2.09 +/- 0.28 (n = 5) for [Val5]AII and 2.2 +/- 0.37 (n = 6) for [Val5]AIII(2-8). The blood clearance rates of exogenous [Val5]AII and [Val5]AIII(2-8) in sodium-depleted sheep were calculated to be 135 +/- 15 liter/hr (n = 10) and 140 +/- 13 liter/hr (n = 10) respectively. Based on these experimental data, a steady-state model of angiotensin metabolism was constructed. If it is assumed that endogenous arterial blood [Val5]AII and [Val5]AIII(2-8) cleared metabolically at a similar rate as exogenous arterial blood angiotensins, it can be calculated that at steady-state 55% of the arterial [Val5]AII conce...Continue Reading

References

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Citations

Feb 1, 1995·Pharmacology & Therapeutics·J R CockcroftD J Webb
May 12, 2004·Molecular and Cellular Endocrinology·Sylvia A S TaitJohn P Coghlan
Aug 23, 1986·Lancet·M J Brown, J Brown
May 1, 1990·Clinical and Experimental Pharmacology & Physiology·D J CampbellA Kladis
Jan 1, 1987·The Journal of Clinical Investigation·D J Campbell
Nov 1, 1996·Heart·A H Danser, M A Schalekamp
Dec 1, 1994·Kidney International·I A DarbyJ P Coghlan
Jan 1, 1989·British Journal of Clinical Pharmacology·M A SchalekampF H Derkx
Apr 24, 1987·The American Journal of Cardiology·D J Webb, J G Collier
Oct 1, 1993·Hypertension·D J CampbellA M Duncan
Mar 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J B BellM Khosla
Jul 1, 1989·International Journal of Radiation Biology·M E RobbinsJ W Hopewell
Aug 13, 1999·The American Journal of Physiology·J BauerN Parekh

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