PMID: 7539839Feb 15, 1995Paper

Angiotensin II activation of a chloride current in rabbit cardiac myocytes

The Journal of Physiology
H MoritaM Endoh

Abstract

1. The effects of angiotensin II (Ang II) on membrane currents were investigated in single ventricular myocytes from the rabbit heart by the whole-cell voltage-clamp method. 2. In the presence of an inhibitor of Ca2+ currents (nifedipine at 3 microM or CdCl2 at 0.3 mM) and a beta-adrenoceptor blocker (bupranolol at 1 microM), 1 microM Ang II significantly increased the membrane conductance. 3. After elimination of K+ from external and internal solutions and its replacement by Cs+, Ang II at 0.1 microM increased an outwardly rectifying current that reached a maximum after about 40 min. The effect was concentration dependent (10(-9)-10(-6) M) and was inhibited by saralasin, an antagonist of Ang II receptors. 4. The reversal potential of the Ang II-induced current in the absence of K+ was compatible with the Cl- equilibrium potential at various external concentrations of Cl-. 5. A Cl- channel blocker, 4,4'-dinitrostilbene-2,2'-disulphonic acid (DNDS, at 5 mM), reversibly decreased the Ang II-induced current. 6. The Ang II-induced current developed when the internal solution contained Ca2+ (pCa 7.2 or 7.0) but not when it contained 10 mM EGTA without Ca2+. 7. Besides developing a Cl- current, Ang II at 1 microM increased the inward...Continue Reading

Citations

Nov 16, 2001·Journal of Molecular and Cellular Cardiology·M A SalasA Mattiazzi
Dec 15, 2005·Heart, Lung & Circulation·M G Vila Petroff, A R Mattiazzi
Nov 18, 2000·The Journal of Physiology·M G PetroffA Mattiazzi
Jul 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuhiko SonoyamaIchiro Hisatome
Mar 10, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuhiko SonoyamaIchiro Hisatome
Aug 10, 2010·Journal of Molecular and Cellular Cardiology·Verónica C De GiustiErnesto A Aiello
Oct 1, 1996·Journal of Cellular Physiology·H FujitaN Yamashita
Aug 23, 2012·World Journal of Hypertension·Hairuo WenLai-Hua Xie
Jan 5, 2000·Physiological Reviews·J R HumeB Horowitz
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni

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