PMID: 8944655Nov 1, 1996Paper

Angiotensin II activation of Ca(2+)-permeant nonselective cation channels in rat adrenal glomerulosa cells

The American Journal of Physiology
D P Lotshaw, F Li

Abstract

A Ca(2+)-permeant, nonselective cation channel was observed in cell-attached and inside-out membrane patches from rat adrenal glomerulosa cells maintained in primary cell culture. In cell-attached patches under near physiological ionic conditions, single-channel currents exhibited a reversal potential near -10 mV, inward rectification, a nearly linear slope conductance between 0 and -80 mV of 17.4 pS, and voltage-dependent block at potentials more negative than -80 mV. Channels exhibiting identical conductance and gating properties were observed in inside-out patches; however, channel gating ran down within minutes in this configuation. In the inside-out configuration, channel gating did not require cytosolic Ca2+ (Ca2+ < 10(-9) M), and inward rectification was relieved by removal of intracellular Mg2+. Relative ionic permeability was calculated using reversal potential measurements from inside-out patches under bi-ionic conditions. The channel discriminated poorly among monovalent cations (PLi > PK > PCs > PNa) and was not significantly permeable to anions. The channel was permeable to Ca2+, exhibiting a relative permeability ratio of 0.29 PCa/PNa) when measured with 110 mM Ca2+ on the intracellular face and a permeability rat...Continue Reading

References

Jul 1, 1990·Pflügers Archiv : European journal of physiology·B Nilius
Apr 1, 1987·Pflügers Archiv : European journal of physiology·H MatsunagaT Hoshi
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J CohenH Rasmussen
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Jul 1, 1988·Clinical and Experimental Pharmacology & Physiology·K J CattG Aguilera

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Citations

May 18, 1999·The American Journal of Physiology·X L ChenP Q Barrett
Jun 13, 2012·Endocrinology·Nick A GuagliardoPaula Q Barrett
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·Jian-Zhong ShenChiu-Yin Kwan
Mar 27, 2004·Physiological Reviews·András Spät, László Hunyady
May 17, 2003·Archives of Oral Biology·Minako AbeTakashi Suzuki

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