PMID: 8945952Nov 1, 1996Paper

Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility

The American Journal of Physiology
K PerssonK E Andersson

Abstract

The mechanisms and mediators of hypertrophic growth secondary to infravesical urinary outflow obstruction are unknown. The renin-angiotensin system has been implicated in vascular and cardiac hypertrophy, but the involvement of angiotensin II (ANG II) as a trophic factor in the lower urinary tract has not been investigated. In this study, the ANG II subtype AT1 receptor antagonist losartan (DuP 753) was administered perorally (15 mg.kg-1.day-1) for 28 days to rats subjected to partial urethral obstruction or sham surgery. Partial urethral obstruction caused a 3.5-fold increase in bladder weight and a 3-fold increase in bladder protein content compared with sham rats. However, no difference was observed in bladder weight or bladder protein content between losartan-treated rats and rats receiving no drug. Cystometric evaluation of bladder function revealed significant increases in micturition volume, bladder capacity, bladder compliance, and spontaneous contractile activity in rats subjected to partial urethral obstruction compared with sham rats. However, bladder function in rats treated with losartan was not different from bladder function in rats receiving no drug. In vitro studies of isolated bladder tissue showed a weak cont...Continue Reading

Citations

Dec 1, 2012·American Journal of Physiology. Renal Physiology·Mitsuharu YoshiyamaWilliam C de Groat
Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner

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