Angiotensin II and noradrenergic transmission in the pithed rat.

Journal of Cardiovascular Pharmacology
H Majewski

Abstract

The norepinephrine (NE) release rate, determined in the pithed rat with stimulated sympathetic outflow (3 Hz), was calculated from the steady-state concentrations of endogenous NE and [3H]NE in the central venous pool after infusion of [3H]NE intraarterially (i.a.). This technique appropriately corrects for NE metabolism and disposition since the [3H]NE closely follows the removal path of neuronally released NE. Infusion of angiotensin II (AII) [0.1 microgram/kg/min, intravenously (i.v.)] failed to increase the NE release rate. A higher rate of infusion of AII (1.0 microgram/kg/min, i.v.) markedly increased the NE release rate. The converting enzyme inhibitor captopril (1 mg/kg, i.v.) and the AII-receptor blocking drug saralasin (10 micrograms/kg/min, i.v.) decreased the NE release rate, indicating a tonic activation of facilitatory prejunctional AII receptors at sympathetic nerve endings. After bilateral nephrectomy, captopril and saralasin did not decrease the NE release rate. This suggests that renin release from the kidney is the primary determinant of AII effects and that local tissue generation of AII is not important Other differences were observed in nephrectomized rats: AII (0.1 microgram/kg/min, i.v.), in contrast to ...Continue Reading

Citations

Feb 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·J H SchwielerP Hjemdahl
May 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·F D RussellR J Summers
Jul 1, 1995·Progress in Cardiovascular Diseases·J M Delehanty, C S Liang
May 1, 1992·Clinical and Experimental Pharmacology & Physiology·S MinatoguchiH Majewski
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·H YokoyamaH Fujiwara
Sep 1, 1993·British Journal of Pharmacology·M Rechtman, H Majewski
Feb 1, 1994·The Journal of Clinical Investigation·B ClemsonR Zelis
Apr 7, 1994·The American Journal of Cardiology·J de ChamplainR Nadeau
Feb 18, 2003·Fundamental & Clinical Pharmacology·Jippe C BaltPieter A van Zwieten

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