Angiotensin II and salt-induced decompensation in Balb/CJ mice is aggravated by fluid retention related to low oxidative stress

American Journal of Physiology. Renal Physiology
Sofia JönssonMichael Hultström

Abstract

Balb/CJ mice are more sensitive to treatment with angiotensin II (ANG II) and high-salt diet compared with C57BL/6J mice. Together with higher mortality, they develop edema, signs of heart failure, and acute kidney injury. The aim of the present study was to identify differences in renal gene regulation that may affect kidney function and fluid balance, which could contribute to decompensation in Balb/CJ mice after ANG II + salt treatment. Male Balb/CJ and C57BL/6J mice were divided into the following five different treatment groups: control, ANG II, salt, ANG II + salt, and ANG II + salt + N-acetylcysteine. Gene expression microarrays were used to explore differential gene expression after treatment and between the strains. Published data from the Mouse Genome Database were used to identify the associated genomic differences. The glomerular filtration rate (GFR) was measured using inulin clearance, and fluid balance was measured using metabolic cages. Gene ontology enrichment analysis of gene expression microarrays identified glutathione transferase (antioxidant system) as highly enriched among differentially expressed genes. Balb/CJ mice had similar GFR compared with C57BL/6J mice but excreted less Na+ and water, although net...Continue Reading

Associated Datasets

References

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Mar 7, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mediha Becirovic-AgicMichael Hultström

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Citations

Mar 7, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mediha Becirovic-AgicMichael Hultström

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Methods Mentioned

BETA
PCR
Assay
urine collected

Software Mentioned

CarTarDis
Gene Ontology Enrichment Analysis Toolkit

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