Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with diabetic macular edema and other retinal disorders

American Journal of Ophthalmology
Hideharu FunatsuSadao Hori

Abstract

To investigate the correlation between angiotensin II (AII) or vascular endothelial growth factor (VEGF) levels in the vitreous fluid and the severity of diabetic macular edema (DME). A case-control study. Vitreous fluid samples were obtained at the time of vitreoretinal surgery from 20 eyes of 20 patients with DME, 6 eyes of 6 diabetic patients without retinopathy, and 14 eyes of 14 nondiabetic patients. The VEGF levels in vitreous fluid and plasma were determined by enzyme-linked immunosorbent assay, while AII levels were measured by radioimmunoassay. The vitreous concentration of VEGF was significantly higher in patients with DME than in nondiabetic patients or diabetic patients without retinopathy (P <.0001 and P <.0001, respectively). Vitreous levels of AII were also higher in patients with DME than in nondiabetic patients (P =.0082). The vitreous concentration of AII was significantly correlated with that of VEGF (P =.0022). Vitreous concentrations of both AII and VEGF were significantly higher in patients with hyperfluorescent DME than in those with hypofluorescent (P =.0228 and P =.0068, respectively). We found that the levels of both AII and VEGF were elevated in the vitreous fluid of patients with hyperfluorescein DME...Continue Reading

Associated Clinical Trials

Dec 4, 2006·John A. Wells, III, M.D., John A. Wells, III, M.D.

References

Aug 1, 1979·Japanese Circulation Journal·H KobayashiM Miyahara
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A H DanserM A Schalekamp
Oct 1, 1988·Ophthalmology·F P NasrallahC L Schepens
Jul 1, 1986·Ophthalmology·G H Bresnick
May 1, 1993·The American Journal of the Medical Sciences·S S FemanR J Workman
Aug 1, 1996·Archives of Ophthalmology·G A LuttyJ Plouét
Jun 17, 1998·Ophthalmology·S E MossB E Klein
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I HyodoY Kotani

❮ Previous
Next ❯

Citations

Feb 5, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Thomas BertelmannStefan Mennel
Nov 15, 2013·Mediators of Inflammation·Andrea RussoFrancesco Semeraro
Jan 2, 2013·Acta Diabetologica·Francesco BandelloClaudia Del Turco
Mar 15, 2008·Seminars in Immunopathology·Anthony P Adamis, Adrienne J Berman
Oct 19, 2002·The British Journal of Ophthalmology·L L Knudsen, H H Lervang
Jul 20, 2004·The British Journal of Ophthalmology·T NagaokaA Yoshida
Dec 18, 2013·Middle East African Journal of Ophthalmology·Saba Al Rashaed, J Fernando Arevalo
Jun 3, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Banu Turgut OzturkSuleyman Okudan
Apr 12, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Rebecca GriersonMichelle Thill
Apr 27, 2012·International Journal of Inflammation·Toshihide KuriharaKazuo Tsubota
Aug 6, 2005·Experimental Eye Research·Masayuki OuchiMotohiro Kamei
Jun 10, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G B JaissleK U Bartz-Schmidt
Oct 6, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hamid AhmadiehMohammad-Reza Mohebbi
Oct 18, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eldad DavidovMichael Happich
Jul 29, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sunali GoyalManju L Subramanian
Nov 27, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano FogliRomano Danesi
Jul 23, 2011·Progress in Neurobiology·John W Wright, Joseph W Harding
Oct 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Robert HennigAchim Goepferich
May 2, 2008·Progress in Retinal and Eye Research·Constantin J PournarasEinar Stefansson
Nov 1, 2006·Progress in Retinal and Eye Research·Sarah X Zhang, Jian-xing Ma
Aug 28, 2014·Diabetes, Obesity & Metabolism·A DasS Rangasamy
Sep 13, 2005·Ophthalmology·Emmett T CunninghamUNKNOWN Macugen Diabetic Retinopathy Study Group
Nov 19, 2003·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Hideharu Funatsu, Hidetoshi Yamashita
Dec 6, 2006·Annals of the New York Academy of Sciences·Eugene W M Ng, Anthony P Adamis
Oct 13, 2009·Fundamental & Clinical Pharmacology·Ulrike Muscha SteckelingsThomas Unger
Dec 20, 2014·Proteomics. Clinical Applications·João P MonteiroCândida T Tomaz
Oct 20, 2006·Expert Opinion on Biological Therapy·Dante J Pieramici, Robert L Avery
Jun 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sónia SimãoGabriela A Silva
Jun 1, 2013·Expert Review of Ophthalmology·Mohamed Al-ShabraweyAmany Tawfik
Jul 9, 2009·Ocular Immunology and Inflammation·Mehmet CakirOmer F Yilmaz
Jan 6, 2004·International Ophthalmology Clinics·John B Christoforidis, Donald J D'Amico
Sep 11, 2004·Eye·M KaratasA Ophir
Apr 27, 2007·Korean Journal of Ophthalmology : KJO·Yong Jae Cha, Sung Jin Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.