Abstract
The sympathoadrenal response to stress includes a profound increase in adrenomedullary catecholamine synthesis driven by stimulation of tyrosine hydroxylase (TH) transcription. We studied the role of Angiotensin II type 1 and 2 (AT(1) and AT(2)) receptors during isolation stress, and under basal conditions. Pretreatment of rats with the AT(1) receptor antagonist candesartan for 14 days prior to isolation completely prevented the stress-induced stimulation of catecholamine synthesis, decreasing tyrosine hydroxylase transcription by preventing the expression of the transcriptional factor, Fos-related antigen 2 (Fra-2). In addition, AT(1) receptor antagonism prevented the stress-induced increase in adrenomedullary AT(2) receptor binding and protein. Treatment of non-stressed, grouped animals under basal conditions with the AT(1) receptor or with PD 123319, an AT(2) receptor antagonist, decreased the adrenomedullary norepinephrine (NE) content and TH transcription. While AT(1) receptor antagonism decreased the levels of Fra-2 and the phosphorylated forms of cAMP responsive element binding protein (pCREB) and EKR2 (p-ERK2, phosphor-p42 MAP kinase), the AT(2) antagonist decreased Fra-2 with no change in the phosphorylation of CREB or...Continue Reading
References
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B GrimaJ Mallet
Jan 1, 1988·Endocrinology·E Castren, J M Saavedra
Jan 1, 1982·Psychoneuroendocrinology·R MisslinP Ropartz
Jun 11, 1993·Nucleic Acids Research·T YoshidaH Iba
Mar 1, 1994·Journal of Neurochemistry·A Goc, M K Stachowiak
Apr 1, 1993·Frontiers in Neuroendocrinology·F A Antoni
Oct 1, 1995·Journal of Neuroendocrinology·G AguileraX Luo
Jul 1, 1996·Journal of Neurochemistry·E L KimM K Stachowiak
May 1, 1997·Endocrinology·C H GelbandC Sumners
May 22, 1997·Oncogene·M MurakamiH Iba
Dec 1, 1999·Neuroscience·B B NankovaE L Sabban
Jun 2, 2000·Biochemical and Biophysical Research Communications·K TakekoshiT Nakai
Jul 7, 2000·Brain Research·Y NishimuraJ M Saavedra
Feb 13, 2001·Trends in Neurosciences·E L Sabban, R Kvetnanský
Aug 23, 2001·Endocrinology·I ArmandoJ M Saavedra
Dec 26, 2001·Journal of Neurochemistry·M CammarotaJ A Rostas
Jan 19, 2002·Hypertension·Kazuhiro TakekoshiToshiaki Nakai
Apr 30, 2002·Neuroendocrinology·Darren S LeongJaun M Saavedra
Apr 17, 2003·Endocrinology·Miroslava JezovaJuan M Saavedra
Citations
May 13, 2006·Cellular and Molecular Neurobiology·Esther L SabbanRichard Kvetnansky
Sep 23, 2011·Cellular and Molecular Neurobiology·Juan M Saavedra
Jan 17, 2007·Molecular Neurodegeneration·Tom N GrammatopoulosW Michael Zawada
Dec 21, 2010·BMC Systems Biology·Gregory M MillerRajanikanth Vadigepalli
Jul 23, 2005·Endothelium : Journal of Endothelial Cell Research·Jeremy A SullivanIan M Bird
May 25, 2010·Psychiatry Research·Thomas F NewtonKen Grasing
Dec 3, 2014·Neurotoxicology and Teratology·Jie LuYingdong Zhang
Nov 6, 2007·Trends in Molecular Medicine·Anastasios LymperopoulosWalter J Koch
Feb 7, 2007·Circulation·Wanpen VongpatanasinPhilip W Shaul
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hae-Jeong NohDong-Yoon Lim
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits
Oct 25, 2008·Endocrinology·Laurent Yvan-CharvetAnnie Quignard-Boulangé
Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Barbara PetersSigrid C Hoffmann
Sep 9, 2017·Cellular and Molecular Neurobiology·J M Saavedra, I Armando
Oct 16, 2004·Biochemical and Biophysical Research Communications·Gonzalo HerradonThomas F Deuel
Sep 20, 2005·Brain Research. Molecular Brain Research·Xiaoping LiuEsther L Sabban