Angiotensin II AT1 and AT2 receptor types regulate basal and stress-induced adrenomedullary catecholamine production through transcriptional regulation of tyrosine hydroxylase

Annals of the New York Academy of Sciences
Ines ArmandoJ M Saavedra

Abstract

The sympathoadrenal response to stress includes a profound increase in adrenomedullary catecholamine synthesis driven by stimulation of tyrosine hydroxylase (TH) transcription. We studied the role of Angiotensin II type 1 and 2 (AT(1) and AT(2)) receptors during isolation stress, and under basal conditions. Pretreatment of rats with the AT(1) receptor antagonist candesartan for 14 days prior to isolation completely prevented the stress-induced stimulation of catecholamine synthesis, decreasing tyrosine hydroxylase transcription by preventing the expression of the transcriptional factor, Fos-related antigen 2 (Fra-2). In addition, AT(1) receptor antagonism prevented the stress-induced increase in adrenomedullary AT(2) receptor binding and protein. Treatment of non-stressed, grouped animals under basal conditions with the AT(1) receptor or with PD 123319, an AT(2) receptor antagonist, decreased the adrenomedullary norepinephrine (NE) content and TH transcription. While AT(1) receptor antagonism decreased the levels of Fra-2 and the phosphorylated forms of cAMP responsive element binding protein (pCREB) and EKR2 (p-ERK2, phosphor-p42 MAP kinase), the AT(2) antagonist decreased Fra-2 with no change in the phosphorylation of CREB or...Continue Reading

References

Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B GrimaJ Mallet
Jun 11, 1993·Nucleic Acids Research·T YoshidaH Iba
Apr 1, 1993·Frontiers in Neuroendocrinology·F A Antoni
May 1, 1997·Endocrinology·C H GelbandC Sumners

❮ Previous
Next ❯

Citations

May 13, 2006·Cellular and Molecular Neurobiology·Esther L SabbanRichard Kvetnansky
Dec 21, 2010·BMC Systems Biology·Gregory M MillerRajanikanth Vadigepalli
Nov 6, 2007·Trends in Molecular Medicine·Anastasios LymperopoulosWalter J Koch
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hae-Jeong NohDong-Yoon Lim
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits
Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Barbara PetersSigrid C Hoffmann
Oct 16, 2004·Biochemical and Biophysical Research Communications·Gonzalo HerradonThomas F Deuel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.