Angiotensin II AT1 receptor antagonism downregulates stress-related gene expression in brain microvessels from spontaneously hypertensive and normotensive rats

Annals of the New York Academy of Sciences
J ZhouJuan M Saavedra

Abstract

We studied the effect of treatment with the Angiotensin II AT(1) receptor antagonist candesartan (0.3 mg/kg/day via osmotic minipumps for 4 weeks compared with administration of vehicle) in brain microvessels in adult spontaneously hypertensive rats (SHR) that were vulnerable to stroke and normotensive control rats (WKY). At the dose administered, candesartan normalized blood pressure in SHR without significantly affecting blood pressure in WKY rats. We performed the gene expression analysis in rat brain microvessels using the Affymetrix Gene Chip Expression Analysis Technique. From a total of 8,799 probe array sets analyzed, we found abundant abnormalities in gene expression in SHR. Because stress has been suggested as a precipitant factor in brain ischemia and treatment with AT(1) receptor antagonist candesartan prevents the hormonal and sympathoadrenal reaction to isolation stress and protects from stress-induced gastric ulcers, we focused on the expression of stress-related genes. We found a higher number of probe array sets modified by candesartan treatment in normotensive WKY rats than in hypertensive SHR. AT(1) receptor blockade decreased the transcription levels of the stress-related tyrosine kinase receptor, stathmin, ...Continue Reading

References

May 1, 1992·Endocrine Reviews·J M Saavedra
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Margaret MayShah Ebrahim
Mar 29, 2003·Brain Research·Pamela EspositoTheoharis C Theoharides
Apr 11, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claudia BregonzioJuan M Saavedra

❮ Previous
Next ❯

Citations

Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiro KatoSubrina Jesmin
Jan 8, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Melissa A Fleegal-DeMottaWilliam A Banks
Apr 14, 2011·Clinical Science·Lauren M WillisSusan C Fagan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

© 2022 Meta ULC. All rights reserved