Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain

Annals of the New York Academy of Sciences
Hiromichi AndoJuan M Saavedra

Abstract

The spontaneously hypertensive rats (SHR) are a genetically hypertensive strain with vulnerability to brain ischemia and stress. In SHR, the brain Angiotensin II (Ang II) system is chronically stimulated, resulting in brain artery remodeling and inflammation. Pretreatment with Ang II AT(1) receptor antagonists protects from brain ischemia and prevents the hormonal and sympathoadrenal response to stress. In addition, the anti-inflammatory effects of AT(1) receptor antagonists are partially responsible for preventing the development of stress-induced gastric ulcers. We asked whether AT(1) receptor antagonists could exert anti-inflammatory effects in the brain vasculature as a mechanism for their protective effects against ischemia. As determined by immunohistochemistry, long-term inhibition of brain AT(1) receptors by peripheral administration of the AT(1) receptor antagonist candesartan (0.3 mg/kg/day for 28 days) normalized the pathologic remodeling, decreased expression of the intercellular adhesion molecule-1 and the number of associated macrophages, and normalized the endothelial nitric oxide synthase expression in cerebral vessels of SHR. The anti-inflammatory effects of AT(1) receptor antagonists may be an important mechan...Continue Reading

References

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Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Haruki YamakawaJuan M Saavedra
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Citations

Aug 16, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sonia VillapolAviva J Symes
Oct 13, 2011·Journal of Neurotrauma·Yan-Hua SangRaymond Tak-Fai Cheung
Apr 8, 2006·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Rainer Schulz, Gerd Heusch
Jan 13, 2016·Journal of Neurology·Antoine KourilskyAntoine F Carpentier
Sep 17, 2005·Pharmacotherapy·Nigel J Dagenais, Fakhreddin Jamali
May 1, 2007·Journal of the American Society of Hypertension : JASH·Rhian M TouyzErnesto L Schiffrin
Sep 22, 2020·Pharmacology & Therapeutics·Jason D Vadhan, Robert C Speth
May 21, 2021·Frontiers in Pharmacology·Osvaldo M BasmadjianClaudia Bregonzio
Oct 30, 2020·Pharmacology, Biochemistry, and Behavior·Sophocles ChrissobolisManoranjan S D'Souza

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