Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress

Annals of the New York Academy of Sciences
C BregonzioJ M Saavedra

Abstract

Cold-restraint stress reduces gastric blood flow and produces acute gastric ulcers. We studied the role of Angiotensin II (Ang II) on gastric blood flow and gastric ulceration during stress. Spontaneously hypertensive rats, a stress-sensitive strain, were pretreated for 14 days with the AT(1) receptor antagonist candesartan before cold-restraint stress. AT(1) blockade increased gastric blood flow 40% to 50%; prevented gastric ulcer formation by 70% to 80%; reduced the increase in adrenomedullary epinephrine and TH mRNA without preventing the stress-induced increase in adrenal corticosterone; decreased the stress-induced expression of tumor necrosis factor alpha (TNF-alpha) and adhesion protein ICAM-1 in arterial endothelium, and neutrophil infiltration in the gastric mucosa; and decreased PGE(2) content. AT(1) receptor blockers prevent stress-induced ulcerations by a combination of gastric blood flow protection, decreased sympathoadrenal activation, anti-inflammatory effects with reduction in TNF-alpha, and ICAM-1 expression, leading to reduced neutrophil infiltration while maintaining the protective glucocorticoid effects and PGE(2) release. Ang II has a crucial role, through stimulation of AT(1) receptors, in the production a...Continue Reading

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Citations

Apr 18, 2012·Journal of Gastroenterology and Hepatology·Akiko ShiotaniKen Haruma
Nov 16, 2013·Biochemical Pharmacology·Donglin ZhuJingping Shi
Feb 14, 2009·Journal of Gastroenterology·Akiko ShiotaniKen Haruma
Sep 17, 2005·Pharmacotherapy·Nigel J Dagenais, Fakhreddin Jamali
Apr 20, 2010·European Journal of Pharmacology·Amr A FouadWafaey Gomaa
Jan 27, 2017·International Urology and Nephrology·Özgür CanSüheyla Apaydin
Feb 1, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Paulo Augusto Carvalho MirandaAntônio Ribeiro-Oliveira
Apr 18, 2021·Cellular and Molecular Neurobiology·Taíz F S BrasilFernando M A Corrêa

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