Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, and vasopressin

Annals of the New York Academy of Sciences
G BaiardiJuan M Saavedra

Abstract

A 2-week pretreatment with an Angiotensin II AT(1) antagonist prevented the adrenomedullary and hormonal response to isolation stress. We studied the effect of life-long treatment with the AT(1) receptor antagonist candesartan, 10 mg/kg/day, or vehicle administered orally in the drinking water from 8 weeks of age on the response to stress of stress-sensitive spontaneously hypertensive rats (SHRs) and their normotensive controls, the Wistar Kyoto (WKY). Rats were submitted to 24-h isolation stress at different times during the treatment. Treatment with candesartan extended the lifespan of SHRs. AT(1) receptor blockade retained its capacity to blunt the response to isolation stress over a long period of treatment. The AT(1) antagonist inhibited epinephrine release in SHR but not in WKY rats during the first 3 months, corticosterone release in SHR and WKY rats during 10 months, and vasopressin release in SHR rats during 18 months of treatment when rats were submitted to isolation stress. There were no changes in vasopressin release in WKY rats during stress or after AT(1) receptor blockade. We conclude that the blockade of the stress response by the AT(1) receptor antagonist is long lasting and differs between stress-prone SHR and...Continue Reading

References

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May 1, 1992·Endocrine Reviews·J M Saavedra
Jun 29, 1999·Cellular and Molecular Neurobiology·M C GilI Armando
Apr 13, 2000·The European Journal of Neuroscience·M E KeckI D Neumann
Apr 11, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claudia BregonzioJuan M Saavedra

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Citations

Aug 15, 2012·Psychopharmacology·Jan Józef BraszkoPiotr Jakubów
Dec 18, 2010·Pflügers Archiv : European journal of physiology·Simon N Thornton
Aug 10, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hye Young KimHee Sun Kim
Apr 27, 2012·International Journal of Inflammation·Toshihide KuriharaKazuo Tsubota
Nov 2, 2014·American Journal of Hypertension·Sonia Villapol, Juan M Saavedra
Feb 29, 2020·Ageing Research Reviews·Marta Gonzalez-FreireRafael de Cabo

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