Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
L NäveriJ M Saavedra

Abstract

The effects of the angiotensin II AT2 receptor ligands CGP 42112 and PD 123319, the AT1 antagonist losartan, and the nonselective angiotensin II antagonist Sar1,Ile8-angiotensin II on the upper limit of CBF autoregulation were studied in pentobarbital-anesthetized rats. Blood pressure was increased by intravenous phenylephrine infusion, while CBF was measured continuously from the parietal cortex by laser-Doppler flowmetry. Intravenous infusions of CGP 42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF. Sar1,Ile8-angiotensin II (4 micrograms kg-1 min-1) had no effect on baseline CBF or CBF autoregulation but antagonized the effect of CGP 42112 and PD 123319. Losartan (10 mg/kg i.v. bolus) reduced baseline blood pressure and CBF and shifted the autoregulation curve toward higher blood pressures. Sar1,Ile8-angiotensin II blocked the effect of losartan on baseline CBF but not on CBF autoregulation. These results suggest that both CGP 42112 and PD 123319 exert their effects on CBF autoregulation through stimulation of angiotensin II AT2 receptors. The mechanism by which losartan affects CBF remains unclear.

References

Jun 1, 1978·Japanese Journal of Pharmacology·N Toda, M Miyazaki
Aug 1, 1992·Neuroreport·C StrömbergJ M Saavedra
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TamakiJ Ogata
Nov 1, 1991·Stroke; a Journal of Cerebral Circulation·A PostiglioneD I Barry
Dec 1, 1991·British Journal of Pharmacology·K F SongF A Mendelsohn
Jan 1, 1990·Circulation Research·F M Faraci, D D Heistad
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N Toda
Aug 30, 1989·Biochemical and Biophysical Research Communications·S WhitebreadM de Gasparo
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C Speth, S I Harik
Jul 11, 1988·The American Journal of Physiology·C A SurmaczG E Mortimore
Jul 1, 1968·The Journal of Clinical Investigation·J C Greenfield, G T Tindall
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R UddmanL Edvinsson
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C StrömbergJ M Saavedra
Aug 1, 1992·Trends in Endocrinology and Metabolism : TEM·P C WongP B Timmermans

❮ Previous
Next ❯

Citations

Dec 10, 1999·Regulatory Peptides·J M Saavedra
Dec 2, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junichi TakadaMitsuo Iida
Dec 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sigurdur T SigurdssonSvend Strandgaard
Apr 26, 2008·Trends in Cardiovascular Medicine·Lars Edvinsson
Feb 24, 2001·Journal of Receptor and Signal Transduction Research·M J Robertson
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L NäveriJ M Saavedra
Oct 16, 1999·Circulation Research·S WinegradJ L Samuel
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Juan M SaavedraYasuaki Nishimura
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·T M EstrupS Strandgaard
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Trine Fischer PedersenSvend Strandgaard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.