Angiotensin II-dependent induction of AT(2) receptor expression after renal ablation

American Journal of Physiology. Renal Physiology
Erika VázquezBruno Escalante

Abstract

Angiotensin (ANG) II can be associated with gene expression regulation. Thus we studied the possible role of ANG II in the regulation of AT(2) mRNA and protein expression. We utilized sham-operated renal ablation rats as well as renal ablation rats pretreated during the first 7 days of the development of renal damage with either the angiotensin-converting inhibitor ramipril, the AT(1) receptor antagonist losartan, or the AT(2) receptor antagonist PD-123319. Renal tissue was analyzed for histological changes and expression of AT(2) receptor mRNA (by RT-PCR) and protein (by immunohistochemistry). To explore the physiological role of AT(2) receptor overexpression in the development of renal damage, blood pressure, urinary protein excretion, and renal damage were evaluated. A time-dependent increase in the expression of AT(2) receptor mRNA and protein was observed at 7, 15, and 30 days after renal ablation. Because these effects were already evident at day 7, the effects of ramipril, losartan, or PD-123319 were tested at this time. The ramipril group and the PD-123319-pretreated group showed inhibition of AT(2) receptor expression, whereas the losartan-pretreated group showed a further increase in AT(2) receptor expression. Inhibit...Continue Reading

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Citations

Sep 6, 2012·Pflügers Archiv : European journal of physiology·Shetal H Padia, Robert M Carey
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ming-Zhi ZhangRaymond C Harris
Sep 17, 2011·American Journal of Physiology. Renal Physiology·Jill W VerlanderSusan M Wall
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