Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls

American Journal of Physiology. Heart and Circulatory Physiology
T KawadaM Sugimachi

Abstract

To better understand the pathophysiological role of angiotensin II (ANG II) in the dynamic autonomic regulation of heart rate (HR), we examined the effects of intravenous administration of ANG II (10 microg.kg(-1).h(-1)) on the transfer function from vagal or sympathetic nerve stimulation to HR in anesthetized rabbits with sinoaortic denervation and vagotomy. In the vagal stimulation group (n = 7), we stimulated the right vagal nerve for 10 min using binary white noise (0-10 Hz). The transfer function from vagal stimulation to HR approximated a first-order low-pass filter with pure delay. ANG II attenuated the dynamic gain from 7.6 +/- 0.9 to 5.8 +/- 0.9 beats.min(-1).Hz(-1) (means +/- SD; P < 0.01) without affecting the corner frequency or pure delay. In the sympathetic stimulation group (n = 7), we stimulated the right postganglionic cardiac sympathetic nerve for 20 min using binary white noise (0-5 Hz). The transfer function from sympathetic stimulation to HR approximated a second-order low-pass filter with pure delay. ANG II slightly attenuated the dynamic gain from 10.8 +/- 2.6 to 10.2 +/- 3.1 beats.min(-1).Hz(-1) (P = 0.049) without affecting the natural frequency, damping ratio, or pure delay. The disproportional suppres...Continue Reading

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Citations

Jul 23, 2014·Clinical and Experimental Hypertension : CHE·Sharanya RameshSofia B Ahmed
Jun 1, 2010·Experimental Physiology·Masaki MizunoMasaru Sugimachi
Jan 16, 2013·Autonomic Neuroscience : Basic & Clinical·Richard E HoytDavid C Randall
Jan 16, 2013·Regulatory Peptides·Denis D DamascenoJorge L Pesquero
Apr 4, 2019·American Journal of Physiology. Renal Physiology·Jing LiWeibin Shi

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