Angiotensin II does not inhibit vagally-induced bradycardia or gastric contractions in the anaesthetized ferret

British Journal of Pharmacology
P L AndrewsP J Harris

Abstract

The effects of angiotensin II (AII) and the analogue Sar1-Leu8-angiotensin II on the changes in heart rate and gastric pressure induced by vagal stimulation were investigated in the urethane-anaesthetized ferret. AII at high doses (500 ng kg-1 i.v.) increased blood pressure and decreased gastric pressure whereas Sar1-Leu8-AII at the same dose had a much smaller effect on blood pressure and no effect on gastric pressure. Intravenous injections or infusions of AII or its analogue did not alter the effect of vagal stimulation on heart rate or gastric motility. Our results do not provide support for the proposal that AII modulates parasympathetic activity at peripheral sites (Potter, 1982a, b).

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Citations

Sep 1, 1985·Journal of the Autonomic Nervous System·S F Hobbs, E K Potter
Sep 1, 1993·British Journal of Pharmacology·M P Rechtman, H Majewski
Apr 1, 1989·Journal of Autonomic Pharmacology·F E LüdtkeF Schubert
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
May 8, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumiko YamakiYoshio Tanaka
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi

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