Angiotensin II early regulated genes in H295R human adrenocortical cells

Physiological Genomics
Damian G RomeroC E Gomez-Sanchez

Abstract

Evidence for the dysregulation of aldosterone synthesis in cardiovascular pathophysiology has renewed interest in the control of its production. Cellular mechanisms by which angiotensin II (ANG II) stimulates aldosterone synthesis in the adrenal zona glomerulosa are incompletely understood. To elucidate the mechanism of intracellular signaling by ANG II stimulation in the adrenal, we have studied immediate-early regulated genes in human adrenal H295R cells using cDNA microarrays. H295R cells were stimulated with ANG II for 3 h. Gene expression was analyzed by microarray technology and validated by real-time RT-PCR. Eleven genes were found to be upregulated by ANG II. These encode the proteins for ferredoxin, Nor1, Nurr1, c6orf37, CAT-1, A20, MBLL, M-Ras, RhoB, GADD45alpha, and a novel protein designated FLJ45273. Maximum expression levels for all genes occurred 3-6 h after ANG II stimulation. This increase was dose dependent and preceded maximal aldosterone production. Other aldosterone secretagogues, K+ and endothelin-1 (ET-1), also induced the expression of these genes with variable efficiency depending on the gene and with lower potency than ANG II. ACTH had negligible effect on gene expression except for the CAT-1 and Nurr1...Continue Reading

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Citations

Oct 29, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shizuka AritomiMichihiro Yoshimura
Sep 30, 2010·Physiological Genomics·Damian G RomeroCelso E Gomez-Sanchez
Jul 11, 2009·Neuroendocrinology·Elise P Gomez Sanchez
Jan 10, 2014·Journal of Molecular Endocrinology·Saulo J A FelizolaHironobu Sasano
Nov 19, 2013·Endocrine Pathology·Saulo J A FelizolaHironobu Sasano
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Jul 6, 2010·Biochemical Pharmacology·Lynn VerstrepenRudi Beyaert
May 12, 2009·Molecular and Cellular Endocrinology·Licy L Yanes, Damian G Romero
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Jun 9, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Yasuhiro NakamuraHironobu Sasano
Jul 1, 2016·Journal of Molecular Endocrinology·Aurelie Nguyen Dinh CatRhian M Touyz
Mar 1, 2007·Physiological Genomics·Damian G RomeroCelso E Gomez-Sanchez
Sep 27, 2007·Physiological Genomics·Damian G RomeroElise P Gomez-Sanchez
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Nov 5, 2005·Endocrinology·Damian G RomeroCelso E Gomez-Sanchez
Feb 17, 2007·Endocrinology·Damian G RomeroCelso E Gomez-Sanchez
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Jan 16, 2014·Endocrinology·Koshiro NishimotoTsugio Seki
Apr 3, 2021·Frontiers in Endocrinology·Jung Soo LimAdina F Turcu

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