PMID: 3766737Oct 1, 1986Paper

Angiotensin II effects on microvascular diameters of in vitro blood-perfused juxtamedullary nephrons

The American Journal of Physiology
P K CarminesL G Navar

Abstract

The purpose of this study was to determine the specific renal microvascular segments that are functionally responsive to angiotensin II (ANG II) and other vasoactive hormones. Experiments were performed on juxtamedullary tissue from captopril-treated rats during perfusion with blood at a constant pressure of 110 mmHg. Epifluorescence videomicroscopy was utilized to measure diameters of arcuate and interlobular arteries (ART), mid- (MA) and late- (LA) afferent arterioles, and efferent arterioles (EA). Norepinephrine (700 nM) significantly decreased, and sodium nitroprusside (380 nM) increased, inside diameters of all segments. Topical application of ANG II (0.01 to 1 nM) induced significant reductions in diameters of all vessel segments: ART, 17.5 +/- 2.0%; MA, 19.6 +/- 2.5%; LA, 13.5 +/- 1.5%; and EA, 16.9 +/- 2.7%. The preglomerular response to ANG II was blocked by saralasin (10 microM) and, in most cases, was dose dependent; however, an initial hypersensitivity to low ANG II doses (30% decrease in diameter) was exhibited by 38% of the preglomerular vessels studied. Under these experimental conditions, single-nephron glomerular filtration rate decreased significantly in response to 0.01 nM ANG II exposure. These observations ...Continue Reading

Citations

Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Nov 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·John J RehoSteven A Fisher
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Gabriela A EppelJames T Pearson
May 12, 2000·American Journal of Physiology. Renal Physiology·E M TolbertL D Dworkin
Jan 11, 2008·American Journal of Physiology. Renal Physiology·Qingli ZhangThomas L Pallone
Nov 14, 2002·American Journal of Physiology. Renal Physiology·Lisa M Harrison-BernardThomas M Coffman
Jul 22, 2005·American Journal of Physiology. Renal Physiology·Kenneth D Mitchell, John J Mullins
Oct 29, 2000·American Journal of Physiology. Renal Physiology·M WalkerL G Navar
Dec 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L Mattson
Jan 4, 2013·American Journal of Physiology. Renal Physiology·Daniela PatinhaFredrik Palm
Feb 23, 2021·American Journal of Physiology. Renal Physiology·Julia SchranklCharlotte Wagner

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