PMID: 7022457Jun 1, 1981Paper

Angiotensin II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney

Proceedings of the National Academy of Sciences of the United States of America
M R Celio, T Inagami

Abstract

The multiple physiologic functions of angiotensin II(AII) are generally supposed to be mediated by the peptide generated in the blood circulation. In addition to this extracellular mechanism of AII formation, we have obtained immunohistochemical evidence for the intracellular synthesis of AII in the kidney. Rats were perfused with fixative, and paraffin sections of the kidneys were processed with antisera against renin (EC 3.4.99.19), AII, and other components of the renin--angiotensin system. Renin immunoreactivity was regularly observed in the epithelioid granular cells in the media of the afferent vessel of the glomerulus. AII immunoreactivity was found to coexist within the same cells. This observation points to an intracellular production of AII in the juxtaglomerular epitheloid granular cells. AII may then be released concomitantly with renin in the interstitial fluid and in the blood. The paracrine secretion of AII could exert a local regulatory influence on the tonus of the glomerular vessels.

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Citations

Nov 1, 1988·Cardiovascular Drugs and Therapy·T InagamiK Higashimori
Jan 1, 1985·Anatomy and Embryology·M R CelioT Inagami
Jan 1, 1982·Histochemistry·R Taugner, D Ganten
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·R TaugnerD Schneider
Sep 20, 2012·Pflügers Archiv : European journal of physiology·Minolfa C PrietoL Gabriel Navar
Dec 1, 2012·Current Hypertension Reports·Jürgen BohlenderHans Imboden
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Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·R TaugnerR Nobiling
Jun 1, 1993·Kidney International·Y KakinumaI Ichikawa
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May 1, 1986·Kidney International·L BarajasT Inagami
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