PMID: 2092060Jan 1, 1990Paper

Angiotensin II immunoreactivity in the vegetative regions of the thoracic and sacral spinal cord of guinea pig and rat

Journal für Hirnforschung
P G GalabovT Dimitrov

Abstract

The localization of angiotensin-II immunoreactivity (Ang-II-IR) has been studied in the thoracic and sacral spinal cord vegetative regions of male and female guinea pigs and rats. Immunoreactivity is located in varicose nerve fibers and axon terminals throughout the studied areas. We have not observed any immunoreactive neurons in these regions. The highest density of IR structures was observed in the thoracic and sacral vegetative networks of both studied species (Galabov and Davidoff, 1976; Galabov, 1978). Additionally IR fibers and terminals were found between the ependymocytes and in close contact with blood vessels. Slight immunostaining of the apical poles of the ependymocytes was observed too. These localizations of the IR fibers and terminals suggest that Ang II has important functional significance in the regulation of the vegetative activity, and plays some role in the local blood flow regulation. As to the origin of the Ang II-IR fibers and terminals most probably they are coming from higher levels of the central nervous system (brainstem and hypothalamus).

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.