PMID: 6170618Jan 1, 1981Paper

Angiotensin II in epitheloid (renin containing) cells of rat kidney

Histochemistry
R Taugner, E Hackenthal

Abstract

The PAP-method was used for immunocytochemical investigations with antisera against angiotensin (ang) I, ang II and renin in kidneys of rats and mice. In 14 rats, ang II was found in the media of the afferent arteriole - both in the region of the JGA and upstream until the interlobular artery. Serial sections alternately reacted for ang II and renin revealed that the octapeptide is contained in the well known renin positive epitheloid cells of the afferent arteriole and, beyond that, together with renin probably in the same "specific" granules. Fixation conditions were critical for the visualization of immunoreactivity With ang I antisera, comparable in terms of titer and affinity to the ang II antisera, specific immunoreactivity could not be found in the kidneys of rats. With horse radish peroxidase and ferritin as tracers it could be shown that the epitheloid cells of the JGA have the ability to pinocytize and incorporate macromolecules into their granules. It is suggested that ang II is taken up by these cells through the same route, Intracellular generation of ang II appears unlikely as an explanation. Functionally the selective uptake of ang II by epitheloid cells might be a specific process, possibly connected with the ne...Continue Reading

References

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Citations

Jan 1, 1982·Histochemistry·R Taugner, D Ganten
Jan 1, 1983·Histochemistry·E Hackenthal, R Taugner
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·R TaugnerD Schneider
Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·K D Mitchell, L G Navar
Jul 1, 1997·Clinical and Experimental Pharmacology & Physiology·L Barajas
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·T InagamiM Naruse
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·R TaugnerR Nobiling
Jun 1, 1993·Kidney International·Y KakinumaI Ichikawa
Sep 16, 1985·Biochemical and Biophysical Research Communications·M KawamuraT Inagami
Jan 1, 1989·Cell Biochemistry and Function·B UvaM A Masini
Oct 1, 1985·Cell Biochemistry and Function·B UvaP Ghiani
Dec 16, 1987·Biochemical and Biophysical Research Communications·K MizunoT Inagami
Sep 1, 1991·Hypertension·T Inagami

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