Angiotensin II increases expression of IP-10 and the renin-angiotensin system in endothelial cells

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Noriko IdeKoichi Node

Abstract

Angiotensin II promotes vascular inflammation, which plays important roles in vascular injury. In this study, we found that angiotensin II-stimulated human endothelial cells increased the release of a CXC chemokine, IP-10, according to an antibody array. IP-10 expression was higher in the endothelium of coronary blood vessels in mice infused with angiotensin II than in control. Quantitative real-time PCR analysis revealed that angiotensin II significantly increased IP-10 mRNA expression compared to control. Pretreatment with valsartan, but not with PD123319, blocked angiotensin II-induced IP-10 mRNA expression. IP-10 levels in conditioned media detected by ELISA increased in response to angiotensin II compared to control, which was blocked by the pretreatment with valsartan. These data indicate that angiotensin II stimulates IP-10 production from endothelial cells via angiotensin II type 1 receptors. In endothelial cells, IP-10 significantly increased mRNA expression of renin, angiotensin-converting enzyme, and angiotensinogen. IP-10 also increased angiotensin II levels in conditioned media compared to control. Angiotensin II significantly increased mRNA expression of renin, angiotensin converting enzyme and angiotensinogen, wh...Continue Reading

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Citations

Nov 28, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nicolas PelischMasakazu Kohno
May 13, 2010·Reproductive Sciences·Faustino R Pérez-LópezHugh S Taylor
Dec 23, 2009·Vascular Pharmacology·Bonnie K Surmi, Alyssa H Hasty
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Apr 21, 2011·Molecular BioSystems·Shakhawan Abdulrahman MustafaMohamed Saiel Saeed Alhamdani
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Oct 17, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Seung-Young YuDae Yeong Lee

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