Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet

Canadian Journal of Physiology and Pharmacology
P S Sunga, S W Rabkin

Abstract

The objective of this study was to explore the action of angiotensin II (AII) on cardiac contractility and cyclic AMP (cAMP) generation by forskolin and isoproterenol in the hypertrophic myocardium of the salt-sensitive Dahl rat. Inbred Dahl S and Dahl R rats that had been on a diet supplemented with 6% NaCl were studied. The functional effects of the interaction of AII and forskolin on cardiac contractility were assessed in the isolated heart preparation. The effect on the cAMP signal transduction pathway was assessed in cardiomyocytes isolated from hearts of Dahl S and R rats. Dahl S rats developed cardiac hypertrophy on a high-salt diet, whereas Dahl R rats did not. Forskolin increased cardiac contractility, which was differently affected by AII, depending on whether the heart was from hypertrophied Dahl S rat or from the control Dahl R rat. AII accentuated forskolin-induced increases in cardiac contractility in hypertrophic hearts but diminished forskolin-induced increases in contractility in the nonhypertrophied hearts. This response was reflected in the cAMP response to forskolin, in that AII decreased forskolin-induced increases in cAMP in the nonhypertrophic heart. AII had the reverse effect in cardiomyocytes from hyper...Continue Reading

Citations

Mar 11, 2004·Journal of Molecular and Cellular Cardiology·Y JamshidiD S Latchman
Dec 28, 1999·Tissue & Cell·J Y Kong, S W Rabkin
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Xiuli LiuRick G Schnellmann
Jun 12, 2002·Cell Death and Differentiation·J F HarrimanR G Schnellmann
Jul 28, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Guoqiang ZhangAllison A Eddy
Sep 13, 2001·American Journal of Physiology. Renal Physiology·X LiuR G Schnellmann
Nov 21, 1997·Biochemical and Biophysical Research Communications·S L WatersR G Schnellmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

© 2021 Meta ULC. All rights reserved