Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways

American Journal of Physiology. Heart and Circulatory Physiology
Madhu V SinghFrançois M Abboud

Abstract

Toll-like receptors (TLR) are key components of the innate immune system that elicit inflammatory responses through the adaptor proteins myeloid differentiation protein 88 (MyD88) and Toll-interleukin receptor domain-containing adaptor protein-inducing interferon-β (TRIF). Previously, we demonstrated that TRIF mediates the signaling of angiotensin II (ANG II)- induced hypertension and cardiac hypertrophy. Since TRIF is activated selectively by TLR3 and TLR4, our goals in this study were to determine the roles of TLR3 and TLR4 in mediating ANG II-induced hypertension and cardiac hypertrophy, and associated changes in proinflammatory gene expression in heart and kidney. In wild-type (WT) mice, ANG II infusion (1,000 ng·kg-1·min-1 for 3 wk) increased systolic blood pressure and caused cardiac hypertrophy. In ANG II-infused TLR4-deficient mice (Tlr4del), hypertrophy was significantly attenuated despite a preserved or enhanced hypertensive response. In contrast, in TLR3-deficient mice (Tlr3-/-), both ANG II-induced hypertension and hypertrophy were abrogated. In WT mice, ANG II increased the expression of several proinflammatory genes in hearts and kidneys that were attenuated in both TLR4- and TLR3-deficient mice compared with WT. ...Continue Reading

References

Nov 27, 1999·Journal of Korean Medical Science·M R AnJ Lee
Sep 13, 2001·Clinical and Experimental Pharmacology & Physiology·T B FraserJ A Whitworth
Dec 15, 2004·Microbes and Infection·Chandrashekhar Pasare, Ruslan Medzhitov
Nov 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dexter L LeeMichael W Brands
Apr 26, 2007·Nature Reviews. Immunology·Luke A J O'Neill, Andrew G Bowie
Sep 19, 2007·The Journal of Experimental Medicine·Tomasz J GuzikDavid G Harrison
Sep 2, 2008·Free Radical Biology & Medicine·Sergey I DikalovKathy K Griendling
Mar 17, 2010·The Journal of Biological Chemistry·Motohiro NishidaHitoshi Kurose
Apr 13, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hilal AyogluBektas Acikgoz
Nov 16, 2010·Cytokine & Growth Factor Reviews·Sibylle von Vietinghoff, Klaus Ley
Apr 20, 2011·Hypertension·Mazen Kurdi, George W Booz
Aug 9, 2011·Journal of Cardiovascular Pharmacology·Kiyohiro OgawaKenji Sunagawa
Feb 14, 2012·Journal of Molecular and Cellular Cardiology·Madhu V SinghMark E Anderson
Mar 9, 2012·American Journal of Nephrology·Menno PruijmMurielle Bochud
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Apr 23, 2013·Antioxidants & Redox Signaling·Augusto C Montezano, Rhian M Touyz
May 2, 2013·Journal of Leukocyte Biology·Estibalitz Laresgoiti-Servitje
May 23, 2014·Immunologic Research·Madhu V SinghFrancois M Abboud
Jun 13, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Madhu V Singh, François M Abboud
Aug 15, 2014·British Journal of Pharmacology·S M KrishnanG R Drummond
Mar 11, 2015·Journal of Atherosclerosis and Thrombosis·Susumu MatsudaMasunori Matsuzaki
Jul 4, 2015·The Journal of Clinical Hypertension·Wei YaoKaijun Niu
Sep 1, 2015·Journal of the American Society of Nephrology : JASN·Ulrich WenzelHeimo Ehmke
Oct 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Wei HuChandrashekhar Pasare
Nov 4, 2015·Nature Reviews. Cardiology·Xiao MengYun Zhang

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Citations

Sep 10, 2020·Journal of Cardiovascular Pharmacology·Vanessa Dela JustinaR Clinton Webb
Nov 20, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yueh-Min LinChih-Yang Huang
Jan 15, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Johannes Wild, Philip Wenzel
Nov 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chang Youn LeeKi-Chul Hwang
Dec 17, 2020·Frontiers in Cardiovascular Medicine·Zheng XiaoHe Huang
Apr 2, 2021·Circulation Research·Stephanie M CicaleseRita C Tostes
Apr 3, 2021·Molecular and Cellular Endocrinology·Elena Cantero-NavarroAlberto Ortiz
Apr 13, 2021·Vascular Pharmacology·Vanessa Dela JustinaR Clinton Webb
Aug 10, 2021·Journal of Molecular and Cellular Cardiology·Abraham L Bayer, Pilar Alcaide

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