Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle

American Journal of Physiology. Heart and Circulatory Physiology
David S WeberKathy K Griendling

Abstract

Increased reactive oxygen species (ROS) are implicated in several vascular pathologies associated with vascular smooth muscle hypertrophy. In the current studies, we utilized transgenic (Tg) mice (Tg(p22smc)) that overexpress the p22(phox) subunit of NAD(P)H oxidase selectively in smooth muscle. These mice have a twofold increase in aortic p22(phox) expression and H(2)O(2) production and thus provide an excellent in vivo model in which to assess the effects of increased ROS generation on vascular smooth muscle cell (VSMC) function. We tested the hypothesis that overexpression of VSMC p22(phox) potentiates angiotensin II (ANG II)-induced vascular hypertrophy. Male Tg(p22smc) mice and negative littermate controls were infused with either ANG II or saline for 13 days. Baseline blood pressure was not different between control and Tg(p22smc) mice. ANG II significantly increased blood pressure in both groups, with this increase being slightly exacerbated in the Tg(p22smc) mice. Baseline aortic wall thickness and cross-sectional wall area were not different between control and Tg(p22smc) mice. Importantly, the ANG II-induced increase in both parameters was significantly greater in the Tg(p22smc) mice compared with control mice. To con...Continue Reading

References

Oct 1, 1995·General Pharmacology·T Schewe
Jun 1, 1994·The American Journal of Physiology·K M MohazzabM S Wolin
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Sep 1, 2000·Regulatory Peptides·K K Griendling, M Ushio-Fukai
Sep 7, 2002·Circulation Research·Puvi N SeshiahKathy K Griendling
Mar 21, 2003·American Journal of Physiology. Cell Physiology·Laura TadlockTushar Patel
Jul 16, 2003·The Journal of Biological Chemistry·Petra RocicKathy K Griendling
Oct 9, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Karine LaudeDavid G Harrison

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Citations

Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Sep 30, 2008·Antioxidants & Redox Signaling·Ravi NistalaJames R Sowers
Feb 14, 2007·Hypertension·Sergey DikalovDavid G Harrison
May 15, 2012·Circulation Research·Bernard LassègueKathy K Griendling
Jul 7, 2011·Hypertension·Heinrich E LobDavid G Harrison
May 7, 2015·Oxidative Medicine and Cellular Longevity·Michael R ManogueDavid S Weber
Nov 5, 2013·Antioxidants & Redox Signaling·Anna KoniorTomasz J Guzik
Sep 9, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Tongda XuDan Chen
Feb 7, 2017·Annals of Vascular Surgery·Nirvana SadaghianlooAlan Dardik
Oct 30, 2015·International Journal of Molecular Sciences·Yosuke KayamaPhilip S Tsao
Oct 22, 2017·Antioxidants & Redox Signaling·Flávia RezendeKatrin Schröder
Feb 13, 2018·Oxidative Medicine and Cellular Longevity·Giuliana GiardinoClaudio Pignata
Jul 4, 2009·Circulation Research·Alicia N LyleKathy K Griendling
Jun 6, 2013·Stroke; a Journal of Cerebral Circulation·Novella CalcinaghiBruno Weber
Jul 26, 2006·Hypertension·Maria Carolina GongoraDavid G Harrison
Jul 16, 2016·Circulation Research·Kathy K GriendlingUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences
Aug 13, 2011·Circulation Research·Jong-Gil ParkGoo Taeg Oh
Jan 31, 2015·Circulation Research·David I Brown, Kathy K Griendling
Apr 9, 2013·Circulation·Hana A ItaniDavid G Harrison
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Cornelius F H MuellerDavid G Harrison
Oct 20, 2018·Antioxidants & Redox Signaling·Rhian M TouyzAugusto C Montezano
Aug 2, 2007·Journal of Cardiovascular Pharmacology·Holly C Williams, Kathy K Griendling
Oct 13, 2009·Journal of Cellular and Molecular Medicine·Laura V González BoscNancy L Kanagy
Jan 19, 2019·British Journal of Pharmacology·Ijeoma E ObiJennifer S Pollock
Sep 23, 2014·The Journal of Clinical Investigation·Annet KiraboDavid G Harrison

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