Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide

International Immunopharmacology
Katsutoshi Yayama, Hiroshi Okamoto

Abstract

Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation.

References

Sep 30, 1991·Biochemical and Biophysical Research Communications·M ViswanathanJ M Saavedra
Nov 30, 1989·Biochemical and Biophysical Research Communications·A T ChiuA L Johnson
Jan 1, 1995·Current Opinion in Nephrology and Hypertension·T Inagami
Oct 9, 1998·Cardiovascular Research·S A Doggrell, L Brown
Jul 30, 1999·Biochemical and Biophysical Research Communications·M AkishitaM Horiuchi
Aug 6, 1999·Cardiovascular Research·H G HutchinsonR E Pratt
Oct 8, 1999·The Journal of Clinical Investigation·Y TsutsumiT Iwasaka
Feb 1, 2000·Trends in Endocrinology and Metabolism : TEM·S Nouet, C Nahmias
Oct 5, 2002·Hypertension·Robert E WiddopDaniel Henrion
Feb 13, 2003·Biochimica Et Biophysica Acta·Katsutoshi YayamaHiroshi Okamoto
May 1, 2004·Circulation·Wendy W BatenburgA H Jan Danser
May 8, 2004·Circulation Research·Sonia BergayaChantal M Boulanger
Dec 13, 2006·Hypertension·Carmine SavoiaErnesto L Schiffrin

❮ Previous
Next ❯

Citations

Jan 15, 2011·Current Hypertension Reports·Daniela Zablocki, Junichi Sadoshima
Apr 3, 2012·Current Hypertension Reports·Vadim Tchaikovski, Gregory Y H Lip
Mar 21, 2012·Antioxidants & Redox Signaling·Daniela Zablocki, Junichi Sadoshima
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Michael Bader
May 5, 2010·Aging Clinical and Experimental Research·Yan-Fang LiShu-Tian Shi
Feb 19, 2013·Journal of the American Society of Hypertension : JASH·Shant Der SarkissianTaben M Hale
Apr 13, 2010·Physiology & Behavior·Annette D de KloetStephen C Woods
Feb 2, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gunanidhi DhangadamajhiManoranjan Ranjit
Oct 7, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y ZhangW Zhang
Jan 9, 2015·Critical Reviews in Food Science and Nutrition·V ManikkamM L Mathai
Sep 29, 2011·Peptides·Rodrigo Azevedo LoiolaMaria Helena Catelli de Carvalho
Sep 6, 2012·Journal of cardiology·Gen-Xiang MaoJing Yan
Aug 5, 2014·Biochemical and Biophysical Research Communications·Yan-Jie LinLow-Tone Ho
Jan 23, 2015·BioMed Research International·Cecilia TufiñoRosa Amalia Bobadilla-Lugo
Jun 11, 2016·Journal of Neurosurgery·Christoph J GriessenauerMohammadali M Shoja
Jan 21, 2017·Journal of Neurosurgery·Christoph J GriessenauerMohammadali M Shoja
Oct 6, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fei JingMasatsugu Horiuchi
Feb 27, 2018·Current Hypertension Reports·Sharon D B de MoraisIrving H Zucker
Jan 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mohammadali M ShojaAaron A Cohen-Gadol
Dec 31, 2010·Korean journal of pediatrics·Min Hyun Cho
Oct 30, 2016·Circulation Research·Julio Gallego-DelgadoAna Rodriguez
Jan 20, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Amanda K StennettRaouf A Khalil
Dec 25, 2012·Journal of Applied Physiology·Ulrike StreitKlara Brixius
Jan 31, 2020·Experimental Physiology·Priscila Ramos de OliveiraAgnaldo Bruno Chies
Dec 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carla Blum-JohnstonSean M Wilson
Nov 11, 2017·The Journal of Clinical Endocrinology and Metabolism·Eugene J BarrettCarolina M Casellini
Sep 5, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Latha RamalingamNaima Moustaid-Moussa
May 28, 2020·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jazmín Flores-MonroyLuisa Martínez-Aguilar
May 28, 2010·The Journal of Pharmacology and Experimental Therapeutics·Almerina BiggiAlberto Montanari
Aug 8, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J PadillaE F Castillo
Mar 29, 2014·International Journal of Immunopathology and Pharmacology·A ZulliR E Widdop
Apr 16, 2021·Canadian Journal of Physiology and Pharmacology·Betzabel Rodríguez-ReyesRosa Amalia Bobadilla Lugo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.