Angiotensin-II induces phosphorylation of ERK1/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic dissection formation

Journal of Molecular Histology
Zhiwei WangMin Zhang

Abstract

The development of acute aortic dissection (AD) is attributed to unbearable wall tension superimposed on disordered of cells and extracellular matrix (ECM) in the aortic wall. Adventitial fibroblasts (AFs) phenotypic differentiation response to stress exhibits essential function to regulate the remolding of vascular. Little is known about the AFs phenotypic differentiation and its possible mechanism in patients with AD. In this study, we examined their roles in AD. Surgical specimens of the aorta from AD patients (n = 10) and controls (n = 10) were tested for α-smooth muscle actin (α-SMA), extracellular signal-regulated kinase 1,2 (ERK1/2) and phospho-ERK1/2 expression, respectively by western blot. When compared with controls, protein levels of α-SMA was significantly decreased and levels of phospho-ERK1/2 was increased significantly in the aortic wall from patients with AD. Immunohistochemistry results showed elevated staining of both α-SMA and phospho-ERK1/2 in the adventitia of the aortic wall from patients with AD, on the contrary, staining of α-SMA in the media was decreased compared with controls. In vitro, the Raf/MEK/ERK pathway was involved in Ang-II-induced phenotypic differentiation and matrix metalloproteinase-2 (M...Continue Reading

References

Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T FreestoneJ T Powell
Mar 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A Zalewski, Y Shi
Apr 1, 1997·American Journal of Respiratory Cell and Molecular Biology·J K BelknapK R Stenmark
Oct 1, 1998·The American Journal of Physiology·M J TangS T Jiang
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·V DavisB T Baxter
Dec 10, 1999·Cardiology Clinics·M A CoadyJ A Elefteriades
Feb 24, 2000·JAMA : the Journal of the American Medical Association·P G HaganK A Eagle
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Dec 18, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koutaro TsunemiMizuo Miyazaki
Jul 8, 2003·The Journal of Pathology·G Gabbiani
Sep 1, 1958·Medicine·A E HIRSTS W KIME
Dec 3, 2003·American Journal of Physiology. Cell Physiology·Ivan A ArenasSandra T Davidge
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan Daugherty, Lisa A Cassis
Mar 9, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gary R GrotendorstMatthew R Duncan
Nov 4, 2004·Biochemical and Biophysical Research Communications·Toshihiro TsurudaTanenao Eto
Jan 27, 2005·Biochemical and Biophysical Research Communications·Maren LuchtefeldBernhard Schieffer
May 4, 2005·Lancet·N SakalihasanO D Defawe
Nov 22, 2005·Biochemical and Biophysical Research Communications·Wei-Li ShenDing-Liang Zhu
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Li LiPing-Jin Gao
Nov 18, 2006·Pathology, Research and Practice·Noriyuki SakataMasaru Kojima
Dec 5, 2006·Biochemical and Biophysical Research Communications·Fang XuWei-cheng Hu
May 26, 2007·The American Journal of Pathology·Boris HinzGiulio Gabbiani
Jun 12, 2008·Annual Review of Genomics and Human Genetics·Dianna M MilewiczHariyadarshi Pannu
Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Feb 24, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G A Antoniou, A D Giannoukas
Mar 20, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E AllaireM Gervais
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Hui Di WangRyan Boyd

❮ Previous
Next ❯

Citations

Feb 29, 2016·European Journal of Medicinal Chemistry·Mei-Lin TangXun Sun
Jan 15, 2016·BMC Cardiovascular Disorders·Ou LiuHongjia Zhang
Nov 17, 2020·Journal of the American Heart Association·Laura E BruijnJan H N Lindeman
Jan 30, 2021·Oxidative Medicine and Cellular Longevity·Fangyuan JiaXiaoping Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.