PMID: 7581259Aug 1, 1995Paper

Angiotensin II induces the expression of c-fos mRNA in the central nervous system of the rat

Clinical and Experimental Hypertension : CHE
C J LebrunT Unger

Abstract

We have investigated the effects of intracerebroventricular injections of angiotensin II in conscious rats on the expression of c-fos messenger RNA (mRNA) in the caudate nucleus, hypothalamus, midbrain and brainstem using semi-quantitative polymerase chain reaction and Northern Blots. RNA analysis revealed the presence of c-fos transcripts in the midbrain and brainstem following icv injections of ANG II. ANG II (1, 10, 100 ng) induced a substantial increase in c-fos mRNA in the brainstem which was significant after 10 ng ANG II, and less after 100 ng. This effect was time-dependent being detectable within 15 minutes and maximal after 60 minutes. This ANG II-induced c-fos mRNA expression was totally inhibited by icv pretreatment with the ANG II-AT1 receptor antagonist, losartan. Our data show for the first time that stimulation of central periventricular AT1 receptors induces the expression of c-fos mRNA in the brain. Thus, ANG II, in addition to its short-term regulatory actions, can participate through transcription factors in neuroplastic processes.

References

Sep 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·H A Robertson
Jun 1, 1992·Pharmacology & Toxicology·U M SteckelingsT Unger
Oct 28, 1991·Neuroscience Letters·N ObermüllerS P Bottari
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B HengererH Thoenen
Oct 1, 1990·Molecular and Cellular Biology·A J NaftilanA S Kraft
Feb 1, 1990·Brain Research. Molecular Brain Research·P R GiriP L Hoffman
Aug 7, 1986·Nature·J I Morgan, T Curran
Nov 1, 1989·Trends in Neurosciences·J I Morgan, T Curran
Dec 22, 1989·Science·J L SonnenbergT Curran
Nov 30, 1989·Biochemical and Biophysical Research Communications·A T ChiuA L Johnson
Aug 30, 1989·Biochemical and Biophysical Research Communications·S WhitebreadM de Gasparo
May 1, 1988·Molecular and Cellular Biology·J M AlmendralR Bravo
Jan 1, 1987·Methods in Enzymology·K B Mullis, F A Faloona
Jan 1, 1987·Annual Review of Physiology·M I Phillips
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein

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Citations

Oct 3, 2003·Biochemical and Biophysical Research Communications·Melissa A Fleegal, Colin Sumners
Nov 1, 1995·Pharmacology & Toxicology·S HöhleT Unger
Feb 23, 2000·The Journal of Experimental Zoology·L P Mayer, C R Propper
Feb 24, 1999·Journal of Cardiovascular Pharmacology·U Stroth, T Unger
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E MoellenhoffT Unger
Jun 28, 2001·Physiological Reviews·J P BurbachH Gainer

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