Angiotensin II modulates catecholamine release into interstitial fluid of canine myocardium in vivo

American Journal of Physiology. Heart and Circulatory Physiology
D M FarrellLouis J Dell'Italia

Abstract

This study tested the hypothesis that exogenous infusion of angiotensin II (ANG II) leads to the release of catecholamines [norepinephrine (NE) and epinephrine (EPI)] into the cardiac interstitial fluid (ISF) space of dogs with adrenals intact (AI) (n = 7) and with adrenals clamped (AC) (n = 5). LV ISF samples were collected at 3-min intervals during administration of ANG II (100 microM ANG II at 1 ml/min for 10 min) to right atrial neurons via their local arterial blood supply and during electrical stimulation of the stellate ganglia of open-chest anesthetized dogs. In AI dogs, ANG II caused ISF NE to increase fivefold (P < 0.05) without a significant increase in coronary sinus (CS) NE. Electrical stimulation (5 ms, 4 Hz, 8-14 V, and 10 min) of the stellate ganglia caused a similar increase in ISF NE (P < 0.05), accompanied by a sevenfold increase in CS NE (P < 0.05). ISF EPI increased greater than sixfold during ANG II infusion (P < 0.05) and during stellate stimulation. However, during ANG II infusions, aorta plasma EPI levels increased fourfold in AI dogs, whereas in AC dogs, CS NE and EPI levels were unaffected during ANG II infusions. Nevertheless, baseline ISF NE and EPI did not differ and increased to a similar extent d...Continue Reading

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Citations

Dec 1, 2007·Clinical Interventions in Aging·Toni L RipleyRobin E Germany
Aug 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allison E GirasoleJean C Hardwick
Jun 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Gerald H HankesLouis J Dell'Italia
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
May 15, 2007·Immunological Reviews·Alicia C ReidRoberto Levi
Jul 31, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Marmar VaseghiAman Mahajan
Apr 7, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Casey A MuellerDane A Crossley
May 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jean C HardwickJeffrey L Ardell
Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Andrew Armour

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