Increasing evidence suggests that endogenous NO inhibits sympathetic outflow in anesthetized animals. However, in a recent study from this laboratory, we were unable to find any evidence of increased renal sympathetic nerve activity (RSNA) in response to blockade of NO synthesis in conscious rabbits. Because angiotensin II (Ang II) increases sympathetic outflow, one factor for this discrepancy may be the difference in the resting level of Ang II, which may be lower in well-trained conscious animals. In the present study, the effects of blockade of NO synthesis with Nomega-nitro-L-arginine methyl ester (L-NAME, 30 mg/kg IV) on resting RSNA with and without a background intravenous infusion of Ang II (10 ng.kg(-1).min(-1)) was investigated in conscious rabbits. Intravenous administration of L-NAME (30 mg/kg) caused an increase in mean arterial blood pressure (MAP, from 80.4+/-2.9 to 92.8+/-2.5; P=.0001) and a decrease in RSNA (from 100+/-0% to 53.4+/-8.6%, P=.0016). When the elevated blood pressure was returned to control by infusion of hydralazine (0.01 to 0.06 mg.kg(-1).min(-1)), RSNA returned to the level before L-NAME administration. During a sustained infusion of Ang II (10 ng.kg(-1).min(-1)), L-NAME increased MAP from 89.2+...Continue Reading
Angiotensin II actions in paraventricular nucleus: functional evidence for neurotransmitter role in efferents originating in subfornical organ
Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure
Analysis of the action of angiotensin II on the baroreflex control of heart rate in conscious rabbits
ANG II receptor blockade and arterial baroreflex regulation of renal nerve activity in cardiac failure
Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-L-arginine methyl ester
Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats
Localization of NADPH diaphorase in neurons of the rostral ventral medulla: possible role of nitric oxide in central autonomic regulation and oxygen chemoreception
Nitric oxide antagonizes the actions of angiotensin II to enhance tubuloglomerular feedback responsiveness
Endogenous angiotensin II has fewer effects but neuronal nitric oxide synthase has excitatory effects on renal sympathetic nerve activity in salt-sensitive hypertension-induced heart failure.
Effects of intravenous brain natriuretic peptide on regional sympathetic activity in patients with chronic heart failure as compared with healthy control subjects
Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia.
Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits.
Central Rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure
Angiotensin II-induced hypertension is modulated by nuclear factor-κBin the paraventricular nucleus.
Effect of chronic nNOS inhibition on blood pressure, vasoactivity, and arterial wall structure in Wistar rats
Cytokine blockade attenuates sympathoexcitation in heart failure: cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus.
Nitric oxide impacts on angiotensin AT2 receptor modulation of high-pressure baroreflex control of renal sympathetic nerve activity in anaesthetized rats
The role of brain angiotensin II (type 2) receptors and nitric oxide in the renal sympathoinhibitory response to acute volume expansion in conscious rats
Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA)
NO and endogenous angiotensin II interact in the generation of renal sympathetic nerve activity in conscious rats
Central Tempol alters basal sympathetic nerve discharge and attenuates sympathetic excitation to central ANG II
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure
Early initiation of ACE inhibitor treatment after acute myocardial infarction--a missed therapeutic opportunity?
Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure
Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure
Effect of acute inhibition of nitric oxide synthesis by L-NAME on cardiovascular responses following peripheral autonomic blockade in rabbits
Evidence of differential control of renal and lumbar sympathetic nerve activity in conscious rabbits
Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii
Update on the theory and management of orthostatic intolerance and related syndromes in adolescents and children
Nitric oxide pathway presumably does not contribute to antianxiety and memory retrieval effects of losartan
Effect of endogenous kinins, prostanoids, and NO on kinin B1 and B2 receptor expression in the rabbit
Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release
Interaction between interleukin‑6 and angiotensin II receptor 1 in the hypothalamic paraventricular nucleus contributes to progression of heart failure
Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise training in male rabbits with heart failure
The organ-specific nitric oxide synthase activity in the interaction with sympathetic nerve activity: a hypothesis.
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.