Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension

C ThananopavarnM P Sambhi


To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day. After a 5-day control period, all subjects had a mild pressor response to the saralasin infusion (p less than 0.01). After 5 days of the diuretic metolazone (5 mg/day), eight of the 15 patients had a vasodepressor response; these responders had a significantly greater increase in plasma renin activity and angiotensin II concentrations than did the non-responders. Sodium deficit differed markedly (p less than 0.001) between the two groups (361 +/- 121 mEq (SD) vs 52 +/- 26 mEq sodium, respectively). The addition of spironolactone (400 mg/day) for 5 days resulted in saralasin responsiveness in all but two patients, both of whom had small sodium deficits. Thus, variability in the natriuretic response to diuretics may affect saralasin testing and limit its clinical utility.


Oct 1, 1976·Biochemical Medicine·J D BarrettM P Sambhi
Mar 27, 1975·The New England Journal of Medicine·D H StreetenT G Dalakos
Jun 5, 1975·The New England Journal of Medicine·W A Pettinger, H C Mitchell
Jan 1, 1978·Clinical Science and Molecular Medicine·P Van HoogdalemF H Leenen
Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·T G DalakosE T Schroeder
Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R M CareyC R Ayers
Mar 1, 1977·Annals of Internal Medicine·L BaerG S Williams
Aug 1, 1977·Annals of Internal Medicine·G H AndersonD H Streeten
Jun 1, 1976·Kidney International·E T SchroederD H Streeten
Dec 2, 1976·The New England Journal of Medicine·H GavrasH R Brunner
Jun 10, 1976·The American Journal of Medicine·D H StreetenT G Dalakos
Jul 15, 1976·The New England Journal of Medicine·A B Ribeiro, L R Krakoff
Nov 1, 1974·The Journal of Clinical Endocrinology and Metabolism·P EggenaC E Wiedeman

Related Concepts

Angiotensin II, Val(5)-
Diastolic Blood Pressure
Dose-Response Relationship, Drug
Hypertensive Disease
Parenteral Infusion
Saralasin Acetate

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.