Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells

Circulation Research
A OtaniY Honda

Abstract

Angiotensin II (Ang II) plays a role in the development of many vascular diseases. In the present study, we have investigated the effect of Ang II on vascular endothelial growth factor (VEGF) receptor expression and VEGF-induced angiogenic activity in bovine retinal microcapillary endothelial cells (BRECs). Ang II induced a significant increase of kinase domain-containing receptor/total liver kinase (KDR/Flk-1) mRNA in a time- and dose-dependent manner, with a maximal 4.3+/-0.8-fold increase after a 4-hour stimulation. Ang II increased the rate of KDR gene transcription by 5.4-fold, whereas the half-life of KDR mRNA was not increased significantly. The increase depended partially on new protein synthesis. The Ang II-induced KDR mRNA increase was inhibited by either [Sar1,Ile8]angiotensin or angiotensin type 1 receptor antagonists but was not significantly altered by angiotensin type 2 receptor antagonists. The PKC inhibitor reduced Ang II-induced KDR mRNA expression by 70+/-15%. The tyrosine kinase inhibitor reduced the Ang II- and phorbol 12-myristate 13-acetate-induced KDR mRNA increases by 35+/-8% and 44+/-26%, respectively. Ang II increased by 3.1-fold the 35S-labeled KDR/Flk-1 immunoprecipitated by a specific antibody to K...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A MillanK J Catt
Sep 1, 1991·The Journal of Clinical Investigation·E F GradyJ E Kalinyak
Aug 30, 1989·Biochemical and Biophysical Research Communications·I LouveauJ M Saez
Oct 31, 1989·Biochemical and Biophysical Research Communications·P RoubertP Braquet
Nov 30, 1989·Biochemical and Biophysical Research Communications·A T ChiuA L Johnson
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A H DanserM A Schalekamp
Aug 30, 1989·Biochemical and Biophysical Research Communications·S WhitebreadM de Gasparo
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P AielloL E Smith
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·M NakajimaV J Dzau
May 1, 1993·The American Journal of the Medical Sciences·S S FemanR J Workman
Aug 1, 1996·The Journal of Clinical Investigation·O V VolpertN P Bouck

❮ Previous
Next ❯

Citations

Feb 3, 2006·Der Pathologe·A M MüllerF E Franke
Dec 21, 2004·Angiogenesis·David C SaneK Bridget Brosnihan
Jan 16, 2002·Current Hypertension Reports·Andrew S Greene, Sandra L Amaral
Mar 11, 2004·Current Hypertension Reports·Donna S HanesMatthew R Weir
Mar 5, 2003·American Journal of Ophthalmology·Hideharu FunatsuSadao Hori
Apr 5, 2003·Journal of Molecular and Cellular Cardiology·Vishnu ChintalgattuLaxmansa C Katwa
Jul 8, 1999·Regulatory Peptides·M de Gasparo, H M Siragy
Feb 25, 2003·Progress in Retinal and Eye Research·A N WitmerR O Schlingemann
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
May 2, 2002·Anti-cancer Drugs·Hitoshi YoshijiHiroshi Fukui
Apr 27, 2012·International Journal of Inflammation·Toshihide KuriharaKazuo Tsubota
Jul 16, 2005·Reproductive Biology and Endocrinology : RB&E·Jeffrey S GilbertMark J Nijland
Nov 6, 2010·Reproductive Biology and Endocrinology : RB&E·Lauren AntonK Bridget Brosnihan
Sep 13, 2008·Pediatric Research·Shakir MohamedJohn M Dagle
Feb 24, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T SugawaraA Kitabatake
Mar 10, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio ImanishiIchiro Nishio
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi ImaizumiKeijiro Saku
Nov 30, 2013·Pharmacology & Therapeutics·Michael J Giese, Robert C Speth
Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Mar 6, 2002·The Journal of Clinical Investigation·Ken SasakiTsutomu Imaizumi
Apr 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Micheline M de Resende, Andrew S Greene
Oct 17, 2008·American Journal of Physiology. Cell Physiology·Gary E StrikerMaria E Marin-Castaño
Feb 28, 2009·Circulation Research·Yajaira Suárez, William C Sessa
Apr 17, 2009·Journal of Human Hypertension·Y TanabeH Yamashita
Jun 7, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Cuneyt K BuharaliogluKafait U Malik
Feb 24, 2012·The Journal of Biological Chemistry·Yuanyuan ChenPhilip D Kiser
Mar 14, 2012·Indian Pediatrics·H S NiranjanM Vasudeva Kamath
Nov 21, 2007·Transgenic Research·Virginie S VervoortElena B Pasquale
Dec 3, 2008·Expert Opinion on Emerging Drugs·Quresh Mohamed, Tien Y Wong
Mar 1, 2006·Expert Opinion on Biological Therapy·Kazuhiko InoFumitaka Kikkawa
Jun 7, 2005·Expert Opinion on Emerging Drugs·Grant M Comer, Thomas A Ciulla
May 5, 2012·The International Journal of Biochemistry & Cell Biology·Hongjin SongRui Wang
May 22, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M AltasI Elmaci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.