Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung

British Journal of Pharmacology
L ZhaoM R Wilkins

Abstract

1. Angiotensin II (AII) binding density and the effect of chronic AII receptor blockade were examined in the rat model of hypoxia-induced pulmonary hypertension. 2. [125I]-[Sar1,Ile2]AII binding capacity was increased in lung membranes from rats exposed to hypoxia (10% fractional inspired O2) for 7 days compared to normal rats (Bmax 108 +/- 12 vs 77 +/- 3 fmol mg-1 protein; P < 0.05), with no significant change in dissociation constant. Competition with specific AII receptor subtype antagonists demonstrated that AT1 is the predominant subtype in both normal and hypoxic lung. 3. Rats treated intravenously with the AT1 antagonist, GR138950C, 1 mg kg-1 day-1 rather than saline alone during 7 days of exposure to hypoxia developed less pulmonary hypertension (pulmonary arterial pressure: 21.3 +/- 1.7 vs 28.3 +/- 1.1 mmHg; P < 0.05), right ventricular hypertrophy (right/left ventricle weight ratio: 0.35 +/- 0.01 vs 0.45 +/- 0.01; P < 0.05) and pulmonary artery remodelling (abundance of thick-walled pulmonary vessels: 9.6 +/- 1.4% vs 20.1 +/- 0.9%; P < 0.05). 4. The reduction in cardiac hypertrophy and pulmonary remodelling with the AT1 antagonist was greater than that achieved by a dose of sodium nitroprusside (SNP) that produced a c...Continue Reading

References

Oct 1, 1976·Journal of Applied Physiology·R M ZakheimM Park
Dec 1, 1991·The American Review of Respiratory Disease·R J WinterJ M Hughes
Sep 30, 1991·Biochemical and Biophysical Research Communications·M ViswanathanJ M Saavedra
Sep 1, 1987·Journal of Applied Physiology·H JinR M Jackson
Nov 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·J C McKenzieR M Klein
Mar 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·R W Caldwell, C M Blatteis
Jul 4, 1995·European Journal of Pharmacology·K L ClarkG M Drew
Jan 1, 1994·British Journal of Pharmacology·A HilditchM J Robertson

❮ Previous
Next ❯

Citations

Aug 26, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Maria E CampianHanno L Tan
Nov 8, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Yoshiyuki TanabeKoichi Nakayama
Sep 21, 2013·Lung·Jing-bin HuangFu Zhang
Dec 26, 2001·Pharmacology & Therapeutics·T K Jeffery, J C Wanstall
Jun 5, 2003·Molecular and Cellular Endocrinology·Siu Yin Lam, Po Sing Leung
Mar 15, 2000·Molecular and Cellular Endocrinology·W P ChanP S Leung
Oct 16, 1999·General Pharmacology·J P DumasM Dumas
Feb 16, 2011·The Journal of Experimental Medicine·Audrey CourboulinSébastien Bonnet
Jul 10, 2001·High Altitude Medicine & Biology·D R Woods, H E Montgomery
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Almaz A AldashevNicholas W Morrell
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·C ChassagneE Teiger
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Ives HubloueMarc Leeman
Mar 25, 2008·Pediatric Research·Rogerio TesslerJaques Belik
Feb 9, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S CameloC Suguihara
Mar 24, 2012·Wilderness & Environmental Medicine·Axel KleinsasserAlex Loeckinger
Apr 9, 2009·Vascular Pharmacology·Juan LiJian-Ming Pei
Feb 26, 2016·Basic Research in Cardiology·Franziska WernerMichaela Kuhn
Apr 1, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jan HergetVaclav Hampl
Oct 7, 2003·Journal of Applied Physiology·Siu Yin LamPo Sing Leung
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S BonnetJ P Savineau
Sep 14, 1999·Journal of Applied Physiology·R R TaylorF M van Bockxmeer
Jan 15, 2003·Progress in Cardiovascular Diseases·T K Jeffery, N W Morrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.