PMID: 8969883Nov 1, 1996Paper

Angiotensin II receptors in the human adrenal gland

Endocrine Research
L BreaultN Gallo-Payet

Abstract

In the present study, we have characterized distribution and pharmacological properties of angiotensin II (Ang II) receptors in human adrenals frozen immediately after removal. Autoradiographic studies indicate that Ang II receptors are present throughout the gland. Co-incubations with DUP 753, a specific antagonist of the AT1 receptor, and with PD 123319, a specific antagonist of the AT2 receptor, reveal that Ang II receptors are mainly of type 2. The AT1 receptors are detected after 16 weeks of gestation at the periphery of the gland. Competition studies and Scatchard analysis reveal a homogenous population of high affinity AT2 binding sites (Kd = 0.68 +/- 0.1 nM). Binding capacities decrease from 1080 +/- 304 fmol/mg protein at 14 weeks to 275 +/- 55 fmol/mg protein at 21 weeks. These results differ from those obtained in adult glands where autoradiographic studies reveal that the AT1 receptors are found mainly in the zona glomerulosa and AT2 receptors mainly in the medulla. These data suggest that the AT2 receptors could be involved in the morphological or functional differentiation of the human fetal adrenal gland.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A MillanK J Catt
Jun 1, 1981·The Journal of Clinical Endocrinology and Metabolism·B R CarrE R Simpson
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·K FujiedaJ S Winter
Jul 1, 1995·Trends in Pharmacological Sciences·C Nahmias, A D Strosberg
May 1, 1995·Hypertension·M de GasparoP B Timmermans
Apr 1, 1995·Kidney International·S ShanmugamC M Llorens-Cortes
Mar 1, 1995·The Journal of Clinical Endocrinology and Metabolism·C R ParkerW E Grizzle
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·T YamadaV J Dzau
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·S VéronneauJ G LeHoux

❮ Previous
Next ❯

Citations

Jan 15, 1999·Endocrine Research·L BreaultN Gallo-Payet
Apr 19, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H NishimuraP Corvol
Jun 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Zeng GuoMichael Stowasser
Jul 21, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Sung-Moon KimBermseok Oh
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R H WorckJ S Petersen
Jan 26, 2005·Endocrine Research·Ian M Bird, J Christina Pattison
Nov 19, 2019·The Journal of Clinical Investigation·Matthew J TaylorWilliam E Rainey
Jul 20, 1999·Molecular and Cellular Endocrinology·W E Rainey
May 12, 2004·Molecular and Cellular Endocrinology·Mary H BassettWilliam E Rainey
Aug 16, 2011·Molecular and Cellular Endocrinology·Namita G HattangadyWilliam E Rainey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.